Chang Yu-Kai, Erickson Kirk I, Aghjayan Sarah L, Chen Feng-Tzu, Li Ruei-Hong, Shih Jia-Ru, Chang Shao-Hsi, Huang Chih-Mao, Chu Chien-Heng
Department of Physical Education and Sport Sciences, National Taiwan Normal University, Taipei, Taiwan.
Institute for Research Excellence in Learning Science, National Taiwan Normal University, Taipei, Taiwan.
Front Aging Neurosci. 2022 Aug 18;14:929789. doi: 10.3389/fnagi.2022.929789. eCollection 2022.
Aging is associated with cognitive decline, increased risk for dementia, and deterioration of brain function. Modifiable lifestyle factors (e.g., exercise, meditation, and social interaction) have been proposed to benefit memory and brain function. However, previous studies have focused on a single exercise modality or a single lifestyle factor. Consequently, the effect of a more comprehensive exercise program that combines multiple exercise modalities and lifestyle factors, as well as examines potential mediators and moderators, on cognitive function and brain health in late middle-aged and older adults remains understudied. This study's primary aim is to examine the effect of a multi-domain exercise intervention on memory and brain function in cognitively healthy late middle-aged and older adults. In addition, we will examine whether apolipoprotein E () genotypes, physical fitness (i.e., cardiovascular fitness, body composition, muscular fitness, flexibility, balance, and power), and brain-derived neurotrophic factor (BDNF) moderate and mediate the exercise intervention effects on memory and brain function.
The Western-Eastern Brain Fitness Integration Training (WE-BFit) is a single-blinded, double-arm, 6-month randomized controlled trial. One hundred cognitively healthy adults, aged 45-70 years, with different risks for Alzheimer's disease (i.e., genotype) will be recruited and randomized into either a multi-domain exercise group or an online educational course control group. The exercise intervention consists of one 90-min on-site and several online sessions up to 60 min per week for 6 months. Working memory, episodic memory, physical fitness, and BDNF will be assessed before and after the 6-month intervention. The effects of the WE-BFit on memory and brain function will be described and analyzed. We will further examine how genotype and changes in physical fitness and BDNF affect the effects of the intervention.
WE-BFit is designed to improve memory and brain function using a multi-domain exercise intervention. The results will provide insight into the implementation of an exercise intervention with multiple domains to preserve memory and brain function in adults with genetic risk levels for Alzheimer's disease.
ClinicalTrials.gov, identifier: NCT05068271.
衰老与认知能力下降、患痴呆症风险增加以及脑功能衰退有关。已提出可改变的生活方式因素（如运动、冥想和社交互动）对记忆和脑功能有益。然而，先前的研究主要集中在单一运动方式或单一生活方式因素上。因此，对于一个更全面的运动计划的效果，即结合多种运动方式和生活方式因素，并研究潜在的中介因素和调节因素，对中老年和老年人认知功能和脑健康的影响仍研究不足。本研究的主要目的是探讨多领域运动干预对认知健康的中老年和老年人记忆及脑功能的影响。此外，我们将研究载脂蛋白E（）基因型、身体素质（即心血管健康、身体成分、肌肉力量、柔韧性、平衡能力和爆发力）以及脑源性神经营养因子（BDNF）是否调节和介导运动干预对记忆和脑功能的影响。
东西方脑健康综合训练（WE-BFit）是一项单盲、双臂、为期6个月的随机对照试验。将招募100名年龄在45至70岁之间、患阿尔茨海默病风险不同（即基因型）的认知健康成年人，并随机分为多领域运动组或在线教育课程对照组。运动干预包括每周一次90分钟的现场课程和几次长达60分钟的在线课程，为期6个月。在6个月干预前后将评估工作记忆、情景记忆、身体素质和BDNF。将描述和分析WE-BFit对记忆和脑功能的影响。我们将进一步研究基因型以及身体素质和BDNF的变化如何影响干预效果。
WE-BFit旨在通过多领域运动干预改善记忆和脑功能。研究结果将为实施多领域运动干预以在有患阿尔茨海默病遗传风险水平的成年人中保持记忆和脑功能提供见解。
ClinicalTrials.gov，标识符：NCT05068271。
