Li Man, Zhou Xueli, Wang Wei, Ji Baoan, Shao Yu, Du Qianyu, Yao Jinghao, Yang Yan
Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China.
Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, USA.
J Clin Transl Hepatol. 2022 Aug 28;10(4):700-710. doi: 10.14218/JCTH.2021.00374. Epub 2022 Feb 11.
Cholangiocarcinoma (CCA) is a highly aggressive biliary tree malignancy with intrahepatic and extra-hepatic subtypes that differ in molecular pathogeneses, epidemiology, clinical manifestations, treatment, and prognosis. The overall prognosis and patient survival remains poor because of lack of early diagnosis and effective treatments. Preclinical studies have become increasingly paramount as they are helpful not only for the study of the fundamental molecular mechanisms of CCA but also for developing novel and effective therapeutic approaches of this fatal cancer. Recent advancements in cell and molecular biology have made it possible to mimic the pathogenicity of human CCA in chemical-mechanical, infection-induced inflammatory, implantation, and genetically engineered animal models. This review is intended to help investigators understand the particular strengths and weaknesses of the currently used animal models of human CCA and their related modeling techniques to aid in the selection of the one that is the best for their research needs.
胆管癌（CCA）是一种侵袭性很强的胆管恶性肿瘤，有肝内和肝外亚型，它们在分子发病机制、流行病学、临床表现、治疗和预后方面存在差异。由于缺乏早期诊断和有效治疗方法，总体预后和患者生存率仍然很差。临床前研究变得越来越重要，因为它们不仅有助于研究CCA的基本分子机制，还有助于开发针对这种致命癌症的新型有效治疗方法。细胞和分子生物学的最新进展使得在化学机械、感染诱导的炎症、植入和基因工程动物模型中模拟人类CCA的致病性成为可能。这篇综述旨在帮助研究人员了解目前使用的人类CCA动物模型及其相关建模技术的特殊优缺点，以帮助选择最适合其研究需求的模型。
