Cardinale Vincenzo, Bragazzi Maria Consiglia, Carpino Guido, Torrice Alessia, Fraveto Alice, Gentile Raffaele, Pasqualino Vincenzo, Melandro Fabio, Aliberti Camilla, Bastianelli Carlo, Brunelli Roberto, Berloco Pasquale Bartolomeo, Gaudio Eugenio, Alvaro Domenico
Department of Medico-Surgical Sciences and Biotechnologies, Polo Pontino, Rome, Italy;
Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Rome, Italy; ; Department of Movement, Human and Health Sciences, Division of Health Sciences, University of Rome "Foro Italico", Rome, Italy;
Hepatobiliary Surg Nutr. 2013 Oct;2(5):272-80. doi: 10.3978/j.issn.2304-3881.2013.10.02.
Cholangiocarcinoma (CCA) is a very heterogeneous cancer from any point of view, including epidemiology, risk factors, morphology, pathology, molecular pathology, modalities of growth and clinical features. Given this heterogeneity, a uniform classification respecting the epidemiologic, pathologic and clinical needs is currently lacking. In this manuscript we discussed the different proposed classifications of CCA in relation with recent advances in pathophysiology and biology of this cancer.
胆管癌(CCA)从任何角度来看都是一种高度异质性的癌症,包括流行病学、危险因素、形态学、病理学、分子病理学、生长方式及临床特征等方面。鉴于这种异质性,目前缺乏一种符合流行病学、病理学及临床需求的统一分类方法。在本手稿中,我们结合该癌症病理生理学和生物学的最新进展,讨论了CCA不同的分类方法。