Le Barr D K, Blecher S R, Moger W H
Arch Androl. 1986;17(3):195-205. doi: 10.3109/01485018608990196.
The XXSxr pseudomale ("sex-reversed") mouse has an apparently normal male phenotype. This is in accordance with Jost's Principle that, in an animal with androgen-producing testes, phenotype will be fully masculinized, irrespective of chromosomal sex. However, the epididymis of this mutant lacks the Initial Segment. Several alternative explanations were proposed. In the present study we examined the primary of these, viz, androgen insufficiency. We studied androgen levels in serum and tissues of the mutant, and we investigated whether injection of exogenous androgens could induce normal development. The XXSxr pseudomale is not deficient in androgens, nor do exogenous additional androgens induce development of the Initial Segment. It would appear that the abnormal genotype acts on the organ phenotype without intervention of androgens.
XXSxr假雄性（“性反转”）小鼠具有明显正常的雄性表型。这与约斯特原理相符，即在具有产生雄激素的睾丸的动物中，无论染色体性别如何，表型都会完全男性化。然而，这种突变体的附睾缺少起始段。提出了几种替代解释。在本研究中，我们研究了其中最主要的一种，即雄激素不足。我们研究了突变体血清和组织中的雄激素水平，并研究了注射外源性雄激素是否能诱导正常发育。XXSxr假雄性小鼠并不缺乏雄激素，额外注射外源性雄激素也不会诱导起始段的发育。似乎异常基因型在没有雄激素干预的情况下作用于器官表型。
