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基于概率分布特征引导的宫颈癌前病变识别

Recognition of Cervical Precancerous Lesions Based on Probability Distribution Feature Guidance.

作者信息

Liu Jun, Sun Xiaoxue, Li Rihui, Peng Yuanxiu

机构信息

College of Information Engineering, Nanchang Hangkong University, Nanchang, Jiangxi, China.

Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.

出版信息

Curr Med Imaging. 2022;18(11):1204-1213. doi: 10.2174/1573405618666220428104541.

Abstract

INTRODUCTION

Cervical cancer is a high incidence of cancer in women and cervical precancerous screening plays an important role in reducing the mortality rate.

METHODS

In this study, we proposed a multichannel feature extraction method based on the probability distribution features of the Acetowhite (AW) region to identify cervical precancerous lesions, with the overarching goal to improve the accuracy of cervical precancerous screening. A k-means clustering algorithm was first used to extract the cervical region images from the original colposcopy images. We then used a deep learning model called DeepLab V3+ to segment the AW region of the cervical image after the acetic acid experiment, from which the probability distribution map of the AW region after segmentation was obtained. This probability distribution map was fed into a neural network classification model for multichannel feature extraction, which resulted in the final classification performance.

RESULTS

Results of the experimental evaluation showed that the proposed method achieved an average accuracy of 87.7%, an average sensitivity of 89.3%, and an average specificity of 85.6%. Compared with the methods that did not add segmented probability features, the proposed method increased the average accuracy rate, sensitivity, and specificity by 8.3%, 8%, and 8.4%, respectively.

CONCLUSION

Overall, the proposed method holds great promise for enhancing the screening of cervical precancerous lesions in the clinic by providing the physician with more reliable screening results that might reduce their workload.

摘要

引言

宫颈癌是女性高发癌症,宫颈癌前病变筛查对降低死亡率起着重要作用。

方法

在本研究中,我们提出了一种基于醋酸白(AW)区域概率分布特征的多通道特征提取方法来识别宫颈癌前病变,总体目标是提高宫颈癌前筛查的准确性。首先使用k均值聚类算法从原始阴道镜图像中提取宫颈区域图像。然后我们使用一个名为DeepLab V3+的深度学习模型对醋酸实验后的宫颈图像的AW区域进行分割,从中获得分割后AW区域的概率分布图。将此概率分布图输入神经网络分类模型进行多通道特征提取,从而得到最终的分类性能。

结果

实验评估结果表明,所提出的方法平均准确率达到87.7%,平均灵敏度为89.3%,平均特异性为85.6%。与未添加分割概率特征的方法相比,所提出的方法平均准确率、灵敏度和特异性分别提高了8.3%、8%和8.4%。

结论

总体而言,所提出的方法有望通过为医生提供更可靠的筛查结果来减轻其工作量,从而在临床上加强宫颈癌前病变的筛查。

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