Silver-Free C-H Activation: Strategic Approaches towards Realizing the Full Potential of C-H Activation in Sustainable Organic Synthesis.

The activation of carbon-hydrogen bonds is considered as one of the most attractive techniques in synthetic organic chemistry because it bears the potential to shorten synthetic routes as well as to produce complementary product scopes compared to traditional synthetic strategies. However, many current methods employ silver salts as additives, leading to stoichiometric metal waste and thereby preventing the full potential of C-H activation to be exploited. Therefore, the development of silver-free protocols has recently received increasing attention. Mechanistically, silver can serve various roles in C-H activation and thus, avoiding the use of silver requires different approaches based on the role it serves in a given process. In this Review, we present the comparison of silver-based and silver-free methods. Focusing on the strategic approaches to develop silver-free C-H activation, we provide the reader with the means to develop sustainable methods for C-H activation.