Clinic of Rheumatology, Department of Medicine (DAME), ASUFC.
Institute of Statistics, Department of Medical Area, University of Udine, Udine.
Rheumatology (Oxford). 2023 Apr 3;62(4):1586-1593. doi: 10.1093/rheumatology/keac470.
Parotid swelling (PSW) is a major predictor of non-Hodgkin's lymphoma (NHL) in primary SS (pSS). However, since detailed information on the time of onset and duration of PSW is scarce, this was investigated to verify whether it may lead to further improved prediction. NHL localization was concomitantly studied to evaluate the role of the parotid gland microenvironment in pSS-related lymphomagenesis.
A multicentre study was conducted among patients with pSS who developed B cell NHL during follow-up and matched controls that did not develop NHL. The study focused on the history of salivary gland and lachrymal gland swelling, evaluated in detail at different times and for different durations, and on the localization of NHL at onset.
PSW was significantly more frequent among the cases: at the time of first referred pSS symptoms before diagnosis, at diagnosis and from pSS diagnosis to NHL. The duration of PSW was evaluated starting from pSS diagnosis, and the NHL risk increased from PSW of 2-12 months to >12 months. NHL was prevalently localized in the parotid glands of the cases.
A more precise clinical recording of PSW can improve lymphoma prediction in pSS. PSW as a very early symptom is a predictor, and a longer duration of PSW is associated with a higher risk of NHL. Since lymphoma usually localizes in the parotid glands, and not in the other salivary or lachrymal glands, the parotid microenvironment appears to be involved in the whole history of pSS and related lymphomagenesis.
腮腺肿胀（PSW）是原发性干燥综合征（pSS）中非霍奇金淋巴瘤（NHL）的主要预测指标。然而，由于关于 PSW 发病时间和持续时间的详细信息很少，因此进行了这项研究以验证其是否可能导致进一步的改善预测。同时研究 NHL 的定位，以评估腮腺微环境在 pSS 相关淋巴发生中的作用。
对在随访期间发生 B 细胞 NHL 的 pSS 患者和未发生 NHL 的匹配对照进行了一项多中心研究。研究重点是唾液腺和泪腺肿胀的病史，在不同时间和不同持续时间进行详细评估，并在发病时对 NHL 的定位进行评估。
PSW 在病例中更为常见：在首次出现 pSS 症状之前的诊断、诊断时以及从 pSS 诊断到 NHL 期间。PSW 的持续时间从 pSS 诊断开始评估，从 PSW 持续 2-12 个月到>12 个月，NHL 的风险增加。NHL 主要定位于病例的腮腺。
更精确地记录 PSW 可以改善 pSS 中的淋巴瘤预测。PSW 作为一种非常早期的症状是一种预测指标，PSW 持续时间较长与 NHL 的风险增加相关。由于淋巴瘤通常定位于腮腺，而不是其他唾液腺或泪腺，因此腮腺微环境似乎参与了整个 pSS 病史和相关淋巴发生。
