KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium; Translational Research Centre for Gastrointestinal Disorders, Center for Intestinal Neuroimmune Interaction, Leuven, Belgium.
KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium; Translational Research Centre for Gastrointestinal Disorders, Center for Intestinal Neuroimmune Interaction, Leuven, Belgium.
Curr Opin Pharmacol. 2022 Oct;66:102285. doi: 10.1016/j.coph.2022.102285. Epub 2022 Sep 2.
Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain and an altered defecation pattern. Depending on the criteria used, it affects between 5 and 10% of the general population and has a serious impact on quality of life. Most patients with IBS show an induction or exacerbation of their symptoms, particularly abdominal pain, after eating certain foods. This raises the question of the role played by food in IBS pathophysiology. In this review, we describe the multiple risk factors of IBS, and we give an overview of the role of food as a trigger of IBS, distinguishing between immune and non-immune reactions to food. We finally highlight recent findings identifying an immune-mediated mechanism underlying food-induced abdominal pain in IBS.
肠易激综合征（IBS）是一种慢性功能性胃肠道疾病，其特征是反复发作的腹痛和排便习惯改变。根据使用的标准不同，它影响一般人群的 5%至 10%，并对生活质量产生严重影响。大多数 IBS 患者在进食某些食物后会出现症状加重，特别是腹痛。这就提出了食物在 IBS 病理生理学中所起作用的问题。在这篇综述中，我们描述了 IBS 的多种危险因素，并概述了食物作为 IBS 触发因素的作用，区分了食物引起的免疫和非免疫反应。最后，我们强调了最近的发现，这些发现确定了一种免疫介导的机制，该机制是 IBS 中食物引起的腹痛的基础。
