Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Research and Development Center, Tehran University of Medical Sciences, Tehran, Iran.
Chemosphere. 2022 Dec;308(Pt 1):136299. doi: 10.1016/j.chemosphere.2022.136299. Epub 2022 Sep 2.
When plastic objects in our surroundings are degraded, they may produce particles ranging in size from 1 to 100 nm therefore called nanoplastics. The environmental chemicals including nanoplastics may be able to affect biological processes in the nuclear level like altering DNA methylation and regulating microRNAs (miRNAs) as well as long non-coding RNAs (lncRNAs) expression and therefore are implicated in chronic human diseases like neoplasms. The regulatory role of miRNAs and lncRNAs in gene expression is appreciated. In vitro as well as in vivo experiments have shown that environmental elements including nanoplastics are able to dysregulate miRNAs and lncRNAs expression with possible genetic consequences that increase the risk of cancer development. In the current article, we review the biological effects of miRNAs and lncRNAs alterations following nanoplastics exposure.
当我们周围的塑料物体降解时，它们可能会产生大小在 1 到 100nm 之间的颗粒，因此被称为纳米塑料。环境中的化学物质包括纳米塑料，可能能够影响核水平的生物过程，如改变 DNA 甲基化和调节 microRNAs（miRNAs）以及长非编码 RNAs（lncRNAs）的表达，因此与肿瘤等慢性人类疾病有关。miRNAs 和 lncRNAs 在基因表达中的调节作用已得到认可。体外和体内实验表明，包括纳米塑料在内的环境因素能够使 miRNAs 和 lncRNAs 的表达失调，可能产生遗传后果，增加癌症发展的风险。在本文中，我们综述了纳米塑料暴露后 miRNAs 和 lncRNAs 改变的生物学效应。
