Roccol'ko G N
Arkh Anat Gistol Embriol. 1987 Apr;92(4):86-92.
By means of the light and electron microscopy methods structural bases of differentiation and contents of endocrine cells of the stomach epithelium have been studied during the white rat pre- and postnatal development. The development of the endocrine epithelial cells occurs in parallel with the exocrinic ones. Endocrine EC-, G-, D-, P-cells are the first to be revealed in composition of the embryonal stomach epithelium, the others--during the early postembryonic period. The differentiation of the endocrine cells is characterized with asynchronism, is accompanied with a gradual development of organells, increasing amount of secretory granules and appearance of polarity in their distribution. By the 30th day of the postnatal development, the amount of the endocrine cells in the stomach epithelium increases by 5 times in comparison to those in the 1-day-old animals, with simultaneous reaching of the high level in specific differentiation.
借助光学显微镜和电子显微镜方法,对白鼠出生前和出生后发育过程中胃上皮内分泌细胞的分化结构基础和含量进行了研究。内分泌上皮细胞的发育与外分泌上皮细胞的发育并行。胚胎期胃上皮组成中最早发现的是内分泌EC细胞、G细胞、D细胞、P细胞,其他细胞则在胚胎后期早期出现。内分泌细胞的分化具有异步性,伴随着细胞器的逐渐发育、分泌颗粒数量的增加以及其分布极性的出现。到出生后第30天,胃上皮中内分泌细胞的数量比1日龄动物增加了5倍,同时特异性分化达到高水平。