Department of Anesthesiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, Liaoning, 110004, P. R. China.
Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, Liaoning, 110012, P. R. China.
BMC Psychiatry. 2022 Sep 5;22(1):590. doi: 10.1186/s12888-022-04233-2.
Depression is a mental disease involving complex pathophysiological mechanisms, and there are many ways to establish depressive mouse models. The purpose of this study is to comprehensively compare the behavioral changes and its mechanism induced by two different models. This study established two depressive mouse models by maternal separation (MS) or lipopolysaccharide (LPS) administration, and added fluoxetine treatment group respectively for comparison. MS induced more apparent anxiety-like behavior while LPS induced more apparent depressive-like behavior. LPS increased peripheral inflammatory factors more apparent, which were mitigated by fluoxetine. MS inhibited the 5-HT system more obviously and was relieved by fluoxetine. LPS triggered stronger immune response in the hippocampus and prefrontal cortex (PFC). MS significantly reduced the expression of neurotrophic proteins and was alleviated by fluoxetine. Overall, LPS induced stronger system inflammation, while MS impaired the function of HPA axis and 5-HT system. Our results will contribute to a deeper understanding of the pathophysiology of different stress-induced depression and will also help researchers select appropriate models of depression for their own needs.
抑郁症是一种涉及复杂病理生理机制的精神疾病，有许多方法可以建立抑郁小鼠模型。本研究旨在全面比较两种不同模型引起的行为变化及其机制。本研究通过母体分离（MS）或脂多糖（LPS）给药分别建立了两种抑郁小鼠模型，并分别添加氟西汀治疗组进行比较。MS 诱导出更明显的焦虑样行为，而 LPS 诱导出更明显的抑郁样行为。LPS 增加外周炎症因子更明显，氟西汀减轻了这种作用。MS 更明显地抑制 5-HT 系统，氟西汀缓解了这种作用。LPS 在海马体和前额叶皮层（PFC）中引发更强的免疫反应。MS 显著降低神经营养蛋白的表达，氟西汀缓解了这一现象。总的来说，LPS 诱导更强的系统炎症，而 MS 损害 HPA 轴和 5-HT 系统的功能。我们的研究结果将有助于更深入地了解不同应激诱导的抑郁症的病理生理学，并将有助于研究人员根据自身需求选择合适的抑郁症模型。
