阻塞性睡眠呼吸暂停低通气综合征患者前庭功能的临床病例对照研究分析。

Clinical case control study analysis of vestibular function in patients with obstructive sleep apnea-hypopnea syndrome.

机构信息

School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.

出版信息

Ann Palliat Med. 2022 Aug;11(8):2685-2694. doi: 10.21037/apm-22-718.

DOI:10.21037/apm-22-718

PMID:36064359

Abstract

BACKGROUND

To investigate the effects of hypoxia degree and sleep duration on vestibular function in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. We made further study of the low oxygen levels of OSAHS and hypoxic duration on the impact of vestibular function, and further studied the OSAHS the longest apnea time and Vestibular Evoked Myogenic Potential (VEMP) abnormal rate and the relationship between the vestibular function of canal paralysis (CP).

METHODS

A total of 87 OSAHS patients and 47 healthy individuals were enrolled in this study. There was no difference in gender, age and body mass index (BMI) values in matched experimental groups. Other diseases of other systems were excluded. All the participants completed sleepiness questionnaires (i.e., the Epworth sleepiness scale and the STOP-BANG questionnaire) and the Dizziness Handicap Inventory (DHI). Additionally, a caloric test, positional test, electrocochleogram, and VEMP test were administered to evaluate the vestibular function of all the participants. A polysomnography (PSG) was also performed.

RESULTS

The current investigation generated the following three major findings: (I) there was a significant correlation between body mass index and canal paresis [CP; P=0.014, odds ratio (OR) =1.791, 95% confidence interval (CI): 1.125-2.851] and a significant positive correlation between the DHI score and VEMP results (P=0.0061, OR =3.667, 95% CI: 1.449-9.276); (II) the CP abnormality rate of the OSAHS group was significantly higher than that of the control group (P<0.05); (III) there was a significant correlation between the longest apnea duration and the DHI score (r=-0.191, P<0.05).

CONCLUSIONS

The abnormality rate of the vestibular function of OSAHS patients is higher than that of healthy people. OSAHS intermittent hypoxia can affect vestibular function in the inner ear, and the longer the duration of prolonged hypoxia, the more serious the vestibular function damage.

摘要

背景

探讨缺氧程度和睡眠持续时间对阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者前庭功能的影响。我们进一步研究了 OSAHS 的低氧水平和缺氧持续时间对前庭功能的影响，并进一步研究了 OSAHS 最长的呼吸暂停时间和前庭诱发肌源性电位（VEMP）异常率与半规管麻痹（CP）之间的关系。

方法

共纳入 87 例 OSAHS 患者和 47 例健康对照者。匹配实验组在性别、年龄和体重指数（BMI）值上无差异。排除其他系统的其他疾病。所有参与者均完成嗜睡问卷（即 Epworth 嗜睡量表和 STOP-BANG 问卷）和眩晕残障程度评定量表（DHI）。此外，还进行了冷热试验、位置试验、电测听和 VEMP 测试，以评估所有参与者的前庭功能。还进行了多导睡眠图（PSG）检查。

结果

本研究得出以下三个主要发现：（I）BMI 与 CP 显著相关[P=0.014，比值比（OR）=1.791，95%置信区间（CI）：1.125-2.851]，DHI 评分与 VEMP 结果呈显著正相关（P=0.0061，OR=3.667，95%CI：1.449-9.276）；（II）OSAHS 组 CP 异常率明显高于对照组（P<0.05）；（III）最长呼吸暂停时间与 DHI 评分呈显著负相关（r=-0.191，P<0.05）。