Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, Piazza Delle Cliniche, 2, 90127, Palermo, Italy.
Ital J Pediatr. 2022 Sep 5;48(1):160. doi: 10.1186/s13052-022-01352-0.
Acute pancreatitis is a disorder of reversible inflammation of the pancreas. Only a few cases are related to infections and the most common pathogens are the viruses responsible for mumps, parotitis, and influenza. Epstein-Barr virus (EBV)-associated acute pancreatitis is a rare condition and it may occur in children and adults.
A 3-year-old female was admitted to the "G. Di Cristina" Children's Hospital in Palermo for vomiting and abdominal pain. Laboratory investigations revealed elevated amylase and lipase, with normal liver function tests. Abdominal ultrasound demonstrated an enlarged pancreas, with hypoechogenic areas; no biliary lithiasis was observed. Infectious disease serology was positive for the presence of EBV VCA IgM and IgG. A diagnosis of EBV-associated acute pancreatitis was made. The patient was treated conservatively and recovered.
Acute pancreatitis is rarely associated with EBV infection; a review of the English literature revealed only 10 pediatric and 6 adult cases. Patients with pancreatitis should always be evaluated for EBV serology, even in the absence of the typical clinical and hematological features of infectious mononucleosis. For these patients, good prognosis is generally expected.
急性胰腺炎是一种胰腺可逆性炎症性疾病。只有少数病例与感染有关，最常见的病原体是引起腮腺炎、流行性腮腺炎和流感的病毒。Epstein-Barr 病毒（EBV）相关性急性胰腺炎是一种罕见的疾病，可发生在儿童和成人中。
一名 3 岁女性因呕吐和腹痛入住巴勒莫的“G. Di Cristina”儿童医院。实验室检查显示淀粉酶和脂肪酶升高，肝功能检查正常。腹部超声显示胰腺肿大，伴有低回声区；未观察到胆石症。传染病血清学检查 EBV VCA IgM 和 IgG 阳性。诊断为 EBV 相关性急性胰腺炎。患者接受保守治疗后康复。
急性胰腺炎很少与 EBV 感染相关；对英文文献的回顾仅发现 10 例儿科和 6 例成人病例。胰腺炎患者应始终进行 EBV 血清学检查，即使没有传染性单核细胞增多症的典型临床和血液学特征。对于这些患者，一般预后良好。
