Arif Aabiya, Chavarria Yeny, Qamar Mohammad Aadil, Tebha Sameer Saleem, Butt Mehwish, Qamar Khulud, Yosufi Abubakr
Medical School, Ziauddin University, Karachi, Sindh, Pakistan.
Department of Neurology, University of California, Irvine, CA, USA.
Neuropsychiatr Dis Treat. 2022 Aug 30;18:1951-1961. doi: 10.2147/NDT.S381018. eCollection 2022.
New-onset refractory status epilepticus (NORSE) has been reported in the scientific literature as a phenomenon associated with the COVID-19 infection. Given the resurgence of the newer variants of COVID-19 added with its multi-system manifestations, this project was conducted to study the clinical picture of NORSE secondary to COVID-19 infection.
Three electronic databases were searched using an extensive search strategy from November 2019 to December 2021. Patients reporting NORSE secondary to COVID-19 were included in this review. The status epilepticus severity score (STESS) was calculated by the study authors for individual patients. Statistical analysis was performed using SPSS version 26 with a -value <0.05 as statistically significant.
After screening, 12 patients were included in this study with a mean age of 61.6 ± 19.0-year olds. The most common type of status epilepticus reported in our study population was non-convulsive status epilepticus (NCSE) (7 out of 12 patients, 58.3%). The linear regression model revealed that STESS scores were significantly influenced by patients' age ( = 0.004) and intra-hospital occurrence (IHO) of status epilepticus ( = 0.026). Overall, 8 patients (66.7%) were discharged without complications.
Given the observed association of STESS with the aging population and IHO of status epilepticus, special attention is due to the caretakers of this population, while further studies are needed to further build upon this review.
科学文献中已报道新发难治性癫痫持续状态（NORSE）是一种与新型冠状病毒肺炎（COVID-19）感染相关的现象。鉴于COVID-19新变种的再次流行及其多系统表现，开展本项目以研究COVID-19感染继发的NORSE的临床情况。
采用广泛的检索策略，检索了2019年11月至2021年12月的三个电子数据库。本综述纳入了报告COVID-19继发NORSE的患者。研究作者为每位患者计算癫痫持续状态严重程度评分（STESS）。使用SPSS 26版进行统计分析，P值<0.05为具有统计学意义。
筛选后，本研究纳入12例患者，平均年龄为61.6±19.0岁。在我们的研究人群中，报告的最常见癫痫持续状态类型是非惊厥性癫痫持续状态（NCSE）（12例患者中有7例，58.3%）。线性回归模型显示，STESS评分受患者年龄（P = 0.004）和癫痫持续状态院内发生率（IHO）（P = 0.026）的显著影响。总体而言，8例患者（66.7%）出院时无并发症。
鉴于观察到STESS与老年人群及癫痫持续状态IHO之间的关联，应对该人群的护理人员给予特别关注，同时需要进一步研究以在本综述的基础上进一步拓展。
