Faculty of Medicine, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Dermatology, Mazandaran University of Medical Sciences, Sari, Iran.
J Cosmet Dermatol. 2023 Feb;22(2):512-516. doi: 10.1111/jocd.15337. Epub 2022 Oct 10.
Periorbital dark circles (PDC) is one of the most common cosmetic issues in today's society. Only moderate degree of improvement has been achieved by various available treatment options. The present study aimed to compare the clinical efficacy of carboxytherapy and fractional CO laser therapy in the management of PDC.
In this split face study, 30 patients with bilateral PDC aged between 23 and 52 years were recruited who underwent carboxytherapy (n = 30) on PDC of one side of the face and fractional CO laser therapy (n = 30) on the PDC of other side. The entire treatment comprised of four sessions of each therapy with an interval of 2 weeks each time. The assessment was based on both subjective methods (patients' satisfaction and physician's judgment) and objective method (based on digital standard photographs). The degree of improvement from the patient's point of view (patient satisfaction) and physician's point of view (physician satisfaction) was assessed in different therapy sessions in comparison with the improvement after first session.
The study included 30 patients with mean age of 38.22 ± 8.3 years. The mean disease duration was 45 ± 12.3 months. After the second therapy session, patients' satisfaction was remarkably better in the fractional CO laser therapy group than the carboxytherapy group, over the time. According to the physician satisfaction, the improvement rate was higher after the second and sixth weeks in the fractional CO laser therapy group than the carboxytherapy group; whereas in other sessions, there were no statistically significant differences. There were no significant side effects observed in either group post-treatment each time.
Fractional CO laser therapy is a better option to treat PDC than carboxytherapy. Also, mild side effects (including erythema, pain, and discomfort) were reported in both groups; with no significant difference between the groups.
眶周色素沉着（PDC）是当今社会最常见的美容问题之一。各种现有治疗方法只能取得中度改善。本研究旨在比较羧基疗法和分数 CO2 激光疗法治疗 PDC 的临床疗效。
在这项分割面部研究中，招募了 30 名年龄在 23 至 52 岁之间、双侧 PDC 的患者，他们一侧面部接受羧基疗法（n=30），另一侧接受分数 CO2 激光疗法（n=30）。整个治疗包括四次治疗，每次治疗间隔 2 周。评估基于主观方法（患者满意度和医生判断）和客观方法（基于数字标准照片）。从患者角度（患者满意度）和医生角度（医生满意度）评估不同治疗阶段与第一次治疗后的改善程度。
该研究纳入了 30 名平均年龄为 38.22±8.3 岁的患者。平均疾病持续时间为 45±12.3 个月。在第二次治疗后，与羧基疗法组相比，分数 CO2 激光疗法组的患者满意度明显更好。根据医生满意度，分数 CO2 激光疗法组在第二次和第六周的改善率高于羧基疗法组；而在其他阶段，两组之间没有统计学差异。每次治疗后，两组均未观察到明显的副作用。
与羧基疗法相比，分数 CO2 激光疗法是治疗 PDC 的更好选择。此外，两组均报告了轻微的副作用（包括红斑、疼痛和不适）；两组之间无显著差异。
