Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
J Cell Mol Med. 2022 Oct;26(19):4875-4885. doi: 10.1111/jcmm.17518. Epub 2022 Sep 6.
Academics generally believe that imbalance between excitation and inhibition of the nervous system is the root cause of epilepsy. However, the aetiology of epilepsy is complex, and its pathogenesis remains unclear. Many studies have shown that epilepsy is closely related to genetic factors. Additionally, the involvement of a variety of tumour-related transcription factors in the pathogenesis of epilepsy has been confirmed, which also confirms the heredity of epilepsy. In this review, we summarize the existing research on a variety of transcription factors and epilepsy and present relevant evidence related to transcription factors that may be targets in epilepsy. This information is of great significance for revealing the in-depth molecular and cellular mechanisms of epilepsy.
学术界普遍认为，神经系统的兴奋与抑制失衡是癫痫的根本原因。然而，癫痫的病因复杂，其发病机制尚不清楚。许多研究表明，癫痫与遗传因素密切相关。此外，多种与肿瘤相关的转录因子参与癫痫的发病机制已得到证实，这也证实了癫痫的遗传性。在这篇综述中，我们总结了目前关于各种转录因子与癫痫的研究，并提出了与可能成为癫痫治疗靶点的转录因子相关的证据。这些信息对于揭示癫痫的深入分子和细胞机制具有重要意义。
