Department of Animal Physiology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Lublin, Poland.
Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland.
Pharmacol Ther. 2019 Jan;193:156-177. doi: 10.1016/j.pharmthera.2018.08.013. Epub 2018 Aug 24.
Evidence from both preclinical and clinical studies suggest the importance of zinc homeostasis in seizures/epilepsy. Undoubtedly, zinc, via modulation of a variety of targets, is necessary for maintaining the balance between neuronal excitation and inhibition, while an imbalance between excitation and inhibition underlies seizures. However, the relationship between zinc signaling and seizures/epilepsy is complex as both extracellular and intracellular zinc may produce either protective or detrimental effects. This review provides an overview of preclinical/behavioral, functional and molecular studies, as well as clinical data on the involvement of zinc in the pathophysiology and treatment of seizures/epilepsy. Furthermore, the potential of targeting elements associated with zinc signaling or homeostasis and zinc levels as a therapeutic strategy for epilepsy is discussed.
临床前和临床研究都表明锌稳态在癫痫发作中的重要性。毫无疑问，锌通过调节多种靶标，对于维持神经元兴奋和抑制之间的平衡是必需的，而兴奋和抑制之间的失衡是癫痫发作的基础。然而，锌信号与癫痫发作的关系是复杂的，因为细胞外和细胞内的锌都可能产生保护或有害的影响。本综述提供了关于锌在癫痫发作的病理生理学和治疗中的作用的临床前/行为、功能和分子研究以及临床数据的概述。此外，还讨论了针对与锌信号或稳态和锌水平相关的靶点作为治疗癫痫的一种策略的潜力。
