Shipov Anna, Lenchner Itzik, Milgram Josh, Libkind Rivka, Klainbart Sigal, Segev Gilad, Bruchim Yaron
Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Vet Rec. 2023 Mar;192(6):e2134. doi: 10.1002/vetr.2134. Epub 2022 Sep 6.
Septic peritonitis (SP) is a common life-threatening condition. The aims of this study were to describe the aetiology, clinicopathological abnormalities, complications, treatment, outcome and prognosis of dogs with SP.
Records of 113 dogs diagnosed and surgically treated for SP between 2004 and 2020 were reviewed.
Overall survival rate was 74.3%. Parameters at presentation that were significantly associated with mortality were lateral recumbency (p = 0.001) and elevated respiratory rate (p = 0.045). Hypotension during or after surgery (p < 0.001), liver injury (p < 0.001) and acute kidney injury (p < 0.001) were also more common in non-survivors. The source of contamination, number of surgeries or the location of perforation in cases of gastrointestinal tract perforation were not associated with mortality. Delta glucose (serum vs. abdominal) was available in 36 out of 113 dogs and the difference was more than 20 mg/dl in only 22 of out 36 (61.1%) cases.
Liver and kidney injuries play a role in mortality, and early diagnosis and intervention are recommended to prevent multiple organ dysfunction and death. The reported high sensitivity of delta glucose is questionable in diagnosis of SP.
化脓性腹膜炎（SP）是一种常见的危及生命的疾病。本研究的目的是描述患有SP的犬的病因、临床病理异常、并发症、治疗、结局和预后。
回顾了2004年至2020年间113只被诊断为SP并接受手术治疗的犬的记录。
总生存率为74.3%。就诊时与死亡率显著相关的参数是侧卧（p = 0.001）和呼吸频率升高（p = 0.045）。非存活犬在手术期间或手术后出现低血压（p < 0.001）、肝损伤（p < 0.001）和急性肾损伤（p < 0.001）也更为常见。胃肠道穿孔病例的污染来源、手术次数或穿孔位置与死亡率无关。113只犬中有36只可获得血糖差值（血清与腹腔），在36只犬中的22只（61.1%）中差值超过20mg/dl。
肝损伤和肾损伤在死亡率中起作用，建议早期诊断和干预以预防多器官功能障碍和死亡。所报道的血糖差值在SP诊断中的高敏感性值得怀疑。
