原发性睾丸淋巴瘤的特征及生存趋势：一项多中心临床研究。

Characteristic features of primary testicular lymphoma and survival trends: a multicenter clinical study.

机构信息

The Affiliated Hospital of Qingdao University, Qingdao, China, People's Republic of China.

出版信息

Hematology. 2022 Dec;27(1):1019-1025. doi: 10.1080/16078454.2022.2119345.

DOI:10.1080/16078454.2022.2119345

PMID:36066282

Abstract

OBJECTIVES

To retrospectively investigate the clinical characteristics, prognosis, treatment, and therapy outcome of Chinese patients with primary testicular lymphoma (PTL).

METHODS

we collected data of 49 PTL patients from four hospitals over 13 years. The median age was 63 years old. We described the clinical characteristics of the patients including the laterality, serum lactate dehydrogenase (LDH), pathology classification, stage, International prognostic index (IPI) scores and more.

RESULTS

Complete remission (CR) was achieved in 34 patients and partial remission (PR) in 3 patients; Progressive disease (PD) was detected in 11 patients, and 10 patients died. The average progression-free survival (PFS) of all patients was 43.92 months, and the average overall survival (OS) was 47.55 months. The Ann Arbor stage, IPI score, and LDH were associated with OS, while Ann Arbor stage, IPI score, LDH, and histotype were significantly associated with PFS. Chemotherapy and radiotherapy following orchiectomy was associated with a significantly longer PFS.

CONCLUSION

Most patients can achieve CR after induced therapy or orchiectomy. However, there are many associated prognostic factors.

摘要

目的

回顾性分析中国原发性睾丸淋巴瘤（PTL）患者的临床特征、预后、治疗及疗效。

方法

我们收集了四家医院 13 年来 49 例 PTL 患者的数据。患者中位年龄为 63 岁。我们描述了患者的临床特征，包括单侧性、血清乳酸脱氢酶（LDH）、病理分类、分期、国际预后指数（IPI）评分等。

结果

34 例患者达到完全缓解（CR），3 例患者达到部分缓解（PR）；11 例患者出现进展（PD），10 例患者死亡。所有患者的平均无进展生存期（PFS）为 43.92 个月，平均总生存期（OS）为 47.55 个月。Ann Arbor 分期、IPI 评分和 LDH 与 OS 相关，而 Ann Arbor 分期、IPI 评分、LDH 和组织学类型与 PFS 显著相关。睾丸切除术联合化疗和放疗与更长的 PFS 显著相关。