Nowack H, Zeiller P, Steck K
Arzneimittelforschung. 1987 Apr;37(4):432-4.
After cutaneous application to rabbits of a solution containing 1% of indomethacin (Elmetacin), concentration-time curves were determined in the skin-layers, in the subcutaneous tissue, in the superficial musculature, in the knee-joint capsule and in plasma. The quantitative assay used on-line fluorimetric detection after separation by HPLC and alkaline hydrolysis. Levels of indomethacin decreased with the depth of the tissue layers at the site of application. Indomethacin concentrations in the examined tissues exceeded plasma concentration at least twice for up to 8 h. Indomethacin was also detectable in the contralateral untreated tissue specimens and in the knee joint capsule.
将含1%吲哚美辛（依托美辛）的溶液经皮肤涂抹于兔后，测定了皮肤层、皮下组织、浅表肌肉组织、膝关节囊及血浆中的浓度-时间曲线。定量分析采用高效液相色谱分离及碱性水解后在线荧光检测法。吲哚美辛的水平在涂抹部位随组织层深度降低。在长达8小时的时间内，所检测组织中的吲哚美辛浓度至少是血浆浓度的两倍。在对侧未处理的组织标本及膝关节囊中也可检测到吲哚美辛。
