Arai S, Masuyoshi S, Fujimoto K
Arzneimittelforschung. 1987 Apr;37(4):441-4.
Cefodizime was compared with cefotaxime (CTX) in regard to its distribution to an inflammatory site (exudate in croton oil-induced granuloma pouch) of rats and its therapeutic effects on experimental infections in such pouches after intravenous injection. Cefodizime levels in rat serum and pouch exudate were higher than those of CTX, and the former compound disappeared from the serum and pouch exudate far more slowly than the latter. In the tests for therapeutic effects, cefodizime showed almost the same degree of inhibitory activity as CTX against growth in pouch exudate of Escherichia coli Ec-7, Proteus mirabilis Pm-428, and Serratia marcescens Sm-390 for which the minimum inhibitory concentrations (MICs) of cefodizime were equal to or greater than the CTX values, and such activity of cefodizime lasted for a longer period than that of CTX. These results suggest that the above pharmacokinetic features of cefodizime compensate for its MICs against organisms displaying lower values for CTX.
比较了头孢地嗪与头孢噻肟（CTX）静脉注射后在大鼠炎症部位（巴豆油诱导的肉芽肿袋中的渗出液）的分布情况及其对此类袋囊中实验性感染的治疗效果。头孢地嗪在大鼠血清和袋囊中渗出液中的水平高于头孢噻肟，且前者从血清和袋囊中渗出液中消失的速度远比后者慢得多。在治疗效果测试中，对于头孢地嗪的最低抑菌浓度（MIC）等于或高于CTX值的大肠埃希菌Ec - 7、奇异变形杆菌Pm - 428和粘质沙雷氏菌Sm - 390，头孢地嗪在抑制袋囊中渗出液生长方面显示出与CTX几乎相同程度的活性，且头孢地嗪的这种活性持续时间比CTX更长。这些结果表明，头孢地嗪上述的药代动力学特征弥补了其对CTX值较低的微生物的MIC。
