Tibout Pauline, Ledjiar Omar, Athale Uma, Rayar Meera, Kulkarni Ketan, Truong Tony, Cellot Sonia, Bittencourt Henrique, Pelland-Marcotte Marie-Claude, Tran Thai Hoa
Division of Pediatric Hematology-Oncology, Charles-Bruneau Cancer Center, CHU Sainte-Justine, University of Montreal, Montreal, Canada.
Unité de recherche clinique appliquée, Research Centre, CHU Sainte-Justine, Montreal, Canada.
Leuk Lymphoma. 2022 Dec;63(13):3208-3216. doi: 10.1080/10428194.2022.2118536. Epub 2022 Sep 6.
The epidemiology of infant acute lymphoblastic leukemia (ALL), hypodiploid ALL, and mixed-phenotype acute leukemia (MPAL) in Canada is unknown. The main objective was to describe the prevalence, prognostic factors, and outcomes of three rare and high-risk ALL subtypes in Canada. This is a retrospective study using the Cancer in Young People-Canada (CYP-C) database. Event-free survival (EFS) and overall survival (OS) were described by the Kaplan-Meier method and compared using the log-rank test. Among 2626 children aged 0-14 years diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) between 2001 and 2018, 227 (8.6%) patients were identified to be infant ALL ( = 139), hypodiploid ALL ( = 43), or MPAL ( = 45). The 5-year EFS/OS was significantly worse in the infant ALL subgroup compared to that of hypodiploid ALL and MPAL. For the entire cohort, presenting White blood cells (WBCs) ≥50 × 10/L was independently associated with worse EFS/OS.
加拿大婴儿急性淋巴细胞白血病（ALL）、亚二倍体ALL和混合表型急性白血病（MPAL）的流行病学情况尚不清楚。主要目的是描述加拿大三种罕见且高危的ALL亚型的患病率、预后因素和结局。这是一项使用加拿大青少年癌症（CYP-C）数据库的回顾性研究。采用Kaplan-Meier方法描述无事件生存期（EFS）和总生存期（OS），并使用对数秩检验进行比较。在2001年至2018年间确诊为B细胞急性淋巴细胞白血病（B-ALL）的2626名0至14岁儿童中，有227名（8.6%）患者被确定为婴儿ALL（n = 139）、亚二倍体ALL（n = 43）或MPAL（n = 45）。与亚二倍体ALL和MPAL相比，婴儿ALL亚组的5年EFS/OS明显更差。对于整个队列，初诊时白细胞（WBC）≥50×10⁹/L与较差的EFS/OS独立相关。
