Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Tuberculosis Center, Vanderbilt University School of Medicine, Nashville, TN, USA; The Aurum Institute, Johannesburg, South Africa.
Microbiol Res. 2022 Nov;264:127174. doi: 10.1016/j.micres.2022.127174. Epub 2022 Aug 23.
RNA editing, while studied thoroughly in humans, has been sporadically described in bacteria, and to our knowledge, has not been reported in Mycobacterium tuberculosis (Mtb). After thorough quality control and validation by repeated sequencing, by comparing sequences from RNA and DNA from high-throughput sequencing data, we report the first finding of three RNA editing events in two Mtb isolates.
RNA 编辑在人类中研究得较为透彻，但在细菌中却鲜有描述，据我们所知，在结核分枝杆菌（Mtb）中尚未有报道。经过反复测序的严格质量控制和验证，我们通过比较来自高通量测序数据的 RNA 和 DNA 序列，报告了在两个 Mtb 分离株中首次发现的三个 RNA 编辑事件。
