University of Maryland, School of Medicine, Baltimore, Maryland, USA,
Department of Otorhinolaryngology - Head and Neck Surgery, Univeristy of Maryland, School of Medicine, Batimore, Maryland, USA.
ORL J Otorhinolaryngol Relat Spec. 2022;84(6):438-446. doi: 10.1159/000524752. Epub 2022 Sep 6.
The study objective was to identify practice patterns in oropharyngeal cancer management from 2010 to 2016 among human papillomavirus (HPV)-associated and non-HPV-associated oropharyngeal squamous-cell carcinoma (OPSCC) patients.
The National Cancer Database was utilized to identify OPSCC patients from 2010 to 2016. Frequency distributions and multivariable analyses were generated to identify practice patterns and predictors of treatment modality.
A total of 35,956 patients with nonmetastatic OPSCC were included. HPV status was not associated with a treatment modality preference. At academic centers, the proportion of HPV-associated OPSCC patients versus non-HPV-associated OPSCC patients undergoing surgical management was similar (35.7%; 35.9%). Community cancer programs treated patients less often surgically but with no significant treatment preference based on HPV status. Within each facility type, HPV status was not a predictor of surgical or nonsurgical management.
HPV association does not appear to significantly influence treatment modality preference among OPSCC patients. The proportion of OPSCC patients undergoing surgical treatment declined from 2010 to 2016.
本研究旨在从 2010 年至 2016 年，确定人乳头瘤病毒（HPV）相关和非 HPV 相关口咽鳞状细胞癌（OPSCC）患者的口咽癌管理实践模式。
本研究利用国家癌症数据库，从 2010 年至 2016 年，确定 OPSCC 患者。通过频率分布和多变量分析，确定治疗方式和预测因素。
共纳入 35956 例非转移性 OPSCC 患者。HPV 状态与治疗方式偏好无关。在学术中心，HPV 相关 OPSCC 患者与非 HPV 相关 OPSCC 患者接受手术治疗的比例相似（35.7%；35.9%）。社区癌症项目的手术治疗比例较低，但 HPV 状态并非手术或非手术治疗的显著预测因素。在每种治疗模式下，HPV 状态均不是手术或非手术治疗的预测因素。
HPV 相关性似乎不会显著影响 OPSCC 患者的治疗方式偏好。2010 年至 2016 年，接受手术治疗的 OPSCC 患者比例有所下降。
