Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
J Infect Chemother. 2022 Dec;28(12):1704-1706. doi: 10.1016/j.jiac.2022.08.026. Epub 2022 Sep 5.
Vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have shown high efficacy in preventing the onset of disease. However, the immune response to infection immediately after the first vaccination remains unknown. We examined the anti-SARS-CoV-2-binding-antibody titers and neutralizing activity in patients who developed coronavirus disease 2019 after the first vaccination. The amount of anti-SARS-CoV-2-binding antibodies and neutralizing activity drastically increased from the first to the second collection. Our results may provide important data on the course of immune response following vaccination.
新型冠状病毒 2 型（SARS-CoV-2）疫苗在预防疾病发生方面显示出了很高的功效。然而，人们对于首次接种疫苗后感染即刻产生的免疫反应还并不清楚。我们检测了在首次接种疫苗后感染 2019 年冠状病毒病的患者体内针对 SARS-CoV-2 的结合抗体滴度和中和活性。从第一次采集到第二次采集，针对 SARS-CoV-2 的结合抗体数量和中和活性都有大幅增加。我们的研究结果可能为接种疫苗后免疫反应的过程提供了重要的数据。
