Rapid determination of perfluorinated compounds in pork samples using a molecularly imprinted phenolic resin adsorbent in dispersive solid phase extraction-liquid chromatography tandem mass spectrometry.

Perfluorinated compounds (PFCs) that bioaccumulate enter the food chain through animals-derived foods and ultimately harm human health. However, these compounds are extensively used, and consequently, it is important to focus on the residual PFCs content in various animal-derived foods. In this work, a molecularly imprinted polymer with surface grooves and rapid mass transfer ability was prepared hydrothermally, applied as an adsorbent to a needle filter device, and combined with LC-MS/MS for the rapid extraction and determination of trace PFCs in pork. This method requires simple equipment (syringe filter), small amount of adsorbent (2 mg), and short operation time (6-8 min) and has a low detection limit (0.011-0.08 ng g), good recovery (89.3-116.3%), and satisfactory intra-day (≤4.0%) and inter-day (≤8.6%) precision. This study provides a new method for assessing the exposure risk of PFCs in complex samples.