Key Laboratory of Public Health Safety of Hebei Province, College of Public Health, Hebei University, Baoding, 071002, China.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, Hebei University, Baoding, 071002, China.
Anal Chim Acta. 2022 Sep 15;1226:340271. doi: 10.1016/j.aca.2022.340271. Epub 2022 Aug 18.
Perfluorinated compounds (PFCs) that bioaccumulate enter the food chain through animals-derived foods and ultimately harm human health. However, these compounds are extensively used, and consequently, it is important to focus on the residual PFCs content in various animal-derived foods. In this work, a molecularly imprinted polymer with surface grooves and rapid mass transfer ability was prepared hydrothermally, applied as an adsorbent to a needle filter device, and combined with LC-MS/MS for the rapid extraction and determination of trace PFCs in pork. This method requires simple equipment (syringe filter), small amount of adsorbent (2 mg), and short operation time (6-8 min) and has a low detection limit (0.011-0.08 ng g), good recovery (89.3-116.3%), and satisfactory intra-day (≤4.0%) and inter-day (≤8.6%) precision. This study provides a new method for assessing the exposure risk of PFCs in complex samples.
全氟化合物（PFCs）具有生物累积性，会通过动物源性食品进入食物链，最终危害人类健康。然而，这些化合物的应用非常广泛，因此，关注各种动物源性食品中的残留 PFCs 含量非常重要。在这项工作中，我们通过水热法制备了具有表面凹槽和快速传质能力的分子印迹聚合物，将其用作针式过滤器装置中的吸附剂，并结合 LC-MS/MS 用于快速提取和测定猪肉中的痕量 PFCs。该方法所需设备简单（注射器过滤器），吸附剂用量少（2mg），操作时间短（6-8min），检测限低（0.011-0.08ng/g），回收率好（89.3-116.3%），日内精密度（≤4.0%）和日间精密度（≤8.6%）均令人满意。本研究为评估复杂样品中 PFCs 的暴露风险提供了一种新方法。
