Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan.
Department of Quality Assurance, Radiation Safety, and Information System, National Institute of Infectious Diseases, Tokyo, Japan.
Vaccine. 2022 Sep 29;40(41):5997-6000. doi: 10.1016/j.vaccine.2022.08.056. Epub 2022 Aug 25.
Coronavirus disease 2019 (COVID-19) vaccine administration started in February 2021 in Japan. As of December 2021, approximately 75% of the population aged ≥12 years had received two doses of vaccine. We conducted a study to investigate vasovagal reactions (VVR) after COVID-19 vaccination using data on adverse events following immunization. The crude reporting rate of VVR (cases/1,000,000 doses) after vaccination was 9.6 in all age groups combined, and was more frequent in the younger age groups: 28.6 and 37.2 in individuals aged 10-19 years and 20-29 years, respectively. In individuals aged 10-29 years, the rate was similar in males and females (33.0 and 34.2, respectively, p = 0.53); but was higher after dose 1 than after dose 2 (57.4 and 8.8, respectively, p < 0.001). Based on these results, caution needs to be exercised when vaccinating adolescents and young adults, especially with dose 1 of COVID-19 vaccines.
2019 年冠状病毒病（COVID-19）疫苗于 2021 年 2 月在日本开始接种。截至 2021 年 12 月，约有 75%的 12 岁以上人群接种了两剂疫苗。我们利用疫苗接种后不良事件的数据进行了一项研究，以调查 COVID-19 疫苗接种后的血管迷走神经反应（VVR）。所有年龄组接种后 VVR（每 100 万剂病例数）的粗报告率为 9.6，年龄较小的组更为常见：10-19 岁和 20-29 岁的个体分别为 28.6 和 37.2。在 10-29 岁的个体中，男性和女性的发生率相似（分别为 33.0 和 34.2，p=0.53）；但第 1 剂后高于第 2 剂（分别为 57.4 和 8.8，p<0.001）。基于这些结果，在为青少年和年轻人接种疫苗时需要谨慎，尤其是接种 COVID-19 疫苗的第 1 剂时更应如此。
