Wamboldt M Z, Insel T R
Behav Neurosci. 1987 Jun;101(3):439-41. doi: 10.1037//0735-7044.101.3.439.
Nulliparous female Sprague-Dawley rats, cannulated in the left lateral ventricle, were ovariectomized and estrogen primed, then either rendered anosmic via intranasal irrigation with zinc sulfate or left with intact olfaction. Forty-eight hr later, after a 2-hr habituation to the test cage, these animals were injected with either intracerebroventricular oxytocin (400 ng in 2 microliter saline) or saline (2 microliter). Only the group receiving both zinc sulfate and oxytocin became maternal. Additionally, approximately one third of the olfaction-intact rats and none of the anosmic rats cannibalized the rat pups. These results are discussed in regard to discrepancies in the literature regarding oxytocin's role in inducing maternal behavior, as well as the functional connection of the olfactory and oxytocin systems.
将左侧脑室插管的未生育雌性斯普拉格-道利大鼠进行卵巢切除并给予雌激素预处理，然后通过用硫酸锌进行鼻腔冲洗使其嗅觉丧失，或保持嗅觉完整。48小时后，在对测试笼适应2小时后，给这些动物脑室内注射催产素（400纳克溶于2微升生理盐水中）或生理盐水（2微升）。只有同时接受硫酸锌和催产素的组表现出母性行为。此外，约三分之一嗅觉完整的大鼠会吃掉幼鼠，而嗅觉丧失的大鼠无一如此。结合文献中关于催产素在诱导母性行为中的作用的差异以及嗅觉和催产素系统的功能联系，对这些结果进行了讨论。
