Wang Peihan, Huang Yanling, Long Jie
The State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, People's Republic of China.
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, 610041, People's Republic of China.
Infect Drug Resist. 2022 Aug 31;15:5099-5110. doi: 10.2147/IDR.S377657. eCollection 2022.
To grasp the current epidemiological situation of maxillofacial space infection and investigate the risk factors contributing to the longer hospitalization of odontogenic space infection in western China.
This retrospective study collected the clinical characteristics from 746 hospitalized patients with maxillofacial space infection and investigated the risk factors associated with longer hospitalization. Pearson's chi-square test and multivariable binary logistic regression were performed for statistical analysis.
A total of 438 males and 308 females were included in this study, aging from 1 to 90 years (mean age 48.6 years). 74.9% cases resulted from odontogenic infections, with the submandibular space being the most commonly involved space (53.7%). Advanced age (OR (>60 y:19-60 y:≤18 y) = 3.784:3.416:1, p < 0.05), treatment before admission (OR = 2.271, p < 0.05) and number of involved spaces (OR (≥4:2-3:1) = 3.204:1.931:1, p < 0.05) were closely related to longer hospitalization. Streptococcus being the most frequently found aerobic bacteria (268/615, 43.6%) of all the bacteria isolated was resistant to clarithromycin (91.5%) and erythromycin (92.8%).
Hospitalization time could be longer for patients with the identified risk factors. Streptococcus, as the most common type of aerobic flora, is highly resistant to clindamycin and erythromycin.
了解颌面部间隙感染的流行病学现状，探讨我国西部地区牙源性间隙感染住院时间延长的危险因素。
本回顾性研究收集了746例颌面部间隙感染住院患者的临床特征，调查了与住院时间延长相关的危险因素。采用Pearson卡方检验和多变量二元logistic回归进行统计学分析。
本研究共纳入438例男性和308例女性，年龄1至90岁（平均年龄48.6岁）。74.9%的病例由牙源性感染引起，其中下颌下间隙是最常受累的间隙（53.7%）。高龄（OR（>60岁：19 - 60岁：≤18岁）= 3.784：3.416：1，p < 0.05）、入院前接受过治疗（OR = 2.271，p < 0.05）和受累间隙数量（OR（≥4个：2 - 3个：1个）= 3.204：1.931：1，p < 0.05）与住院时间延长密切相关。在所有分离出的细菌中，链球菌是最常见的需氧菌（268/615，43.6%），对克拉霉素（91.5%）和红霉素（92.8%）耐药。
具有已确定危险因素的患者住院时间可能更长。链球菌作为最常见的需氧菌群类型，对克林霉素和红霉素高度耐药。
