Xu L P, Bai F, Tao H
Department of Ophthalmology, The Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China.
Lacrimal Center, Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100039, China.
Zhonghua Yan Ke Za Zhi. 2022 Sep 11;58(9):722-726. doi: 10.3760/cma.j.cn112142-20220130-00044.
Lacrimal gland injection of botulinum toxin type A inhibits the secretion of tears. As a new method to treat or alleviate the symptom of tears or epiphora, it has the characteristics of simple operation, definite curative effect, repeatable treatment and no irreversible complications. It provides an optional treatment scheme for many patients with refractory tears or epiphora. This article reviews the pharmacological characteristics of botulinum toxin type A, the mechanism of inhibiting tear secretion, the method and dose of lacrimal gland injection, indications and contraindications, clinical efficacy evaluation, complications, existing problems to be solved and prospects for reference.
A型肉毒杆菌毒素泪腺注射可抑制泪液分泌。作为一种治疗或缓解流泪或溢泪症状的新方法,它具有操作简单、疗效确切、可重复治疗且无不可逆并发症的特点。它为许多难治性流泪或溢泪患者提供了一种可选的治疗方案。本文综述了A型肉毒杆菌毒素的药理特性、抑制泪液分泌的机制、泪腺注射方法及剂量、适应证和禁忌证、临床疗效评估、并发症、有待解决的现存问题及前景以供参考。