Department of Urology, University of Health Sciences, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, 16000, Turkey.
Department of Urology, Nusaybin State Hospital, Mardin, 47200, Turkey.
Urol J. 2022 Nov 8;19(5):386-391. doi: 10.22037/uj.v19i.7227.
To evaluate whether there were any changes in the rates of urinary tract infection (UTI) and antibiotic resistance in pediatric patients during the pandemic period.
Urine culture samples collected due to suspected UTI were searched retrospectively from our hospital database, and the patients with growth in urine culture were identified. They were divided into 2 groups as Group A (before COVID-19, March 11, 2019- March 11, 2020) and Group B (COVID-19 period, March 11, 2020- March 11, 2021). Also, COVID-19 period was divided into 3 subgroups (March 2020- June 2020: first epidemic peak, July 2020 - November 2020: normalization process, December 2020- March 2021: second epidemic peak). We adjusted the patient age as <1, 1-6 and 7-18 years. Age, gender, microorganism strain types, and their antibiotic resistance patterns were compared between the 2 groups Results: This cross-sectional study included 250 eligible patients (Group A, n=182 and Group B, n=68) with a mean age of 10.91 ± 5.58 years. The male/female ratio was higher in Group B than in Group A (p = .004). Incidence of UTIs was lower in the curfew and restriction periods due to epidemic peaks than normalization process (p = .001). The proportion of E.coli decreased from 80.2% to 61.8% during the pandemic period when compared to pre-pandemic period (p = .001). Group B had lower rates of resistance to ampicillin, fosfomycin and nitrofurantoin for E.coli than Group A (p = .001, p = .012 and p = .001, respectively). Also, Group B had higher rate of uncommon microorganisms and lower rate of resistance to nitrofurantoin for E.coli than Group A in patients aged 7-18 years (p = .003 and p = .023, respectively).
Our study demonstrates that the ongoing COVID-19 pandemic process has caused alterations in community-acquired UTIs in children. More hygienic lifestyle may be considered as the main factor in this change.
评估在大流行期间，儿科患者的尿路感染（UTI）发生率和抗生素耐药率是否发生变化。
我们从医院数据库中回顾性搜索了因疑似 UTI 而采集的尿培养样本，并确定了尿液培养中生长的患者。他们被分为 2 组，A 组（COVID-19 前，2019 年 3 月 11 日-2020 年 3 月 11 日）和 B 组（COVID-19 期间，2020 年 3 月 11 日-2021 年 3 月 11 日）。此外，COVID-19 期间还分为 3 个亚组（2020 年 3 月-2020 年 6 月：第一波疫情高峰，2020 年 7 月-2020 年 11 月：正常化过程，2020 年 12 月-2021 年 3 月：第二波疫情高峰）。我们将患者年龄调整为<1、1-6 和 7-18 岁。比较了两组之间的年龄、性别、微生物菌株类型及其抗生素耐药模式。结果：这项横断面研究纳入了 250 名符合条件的患者（A 组，n=182；B 组，n=68），平均年龄为 10.91±5.58 岁。B 组的男/女比例高于 A 组（p=0.004）。由于疫情高峰期的封锁和限制，UTI 的发病率低于正常化过程（p=0.001）。与大流行前相比，大肠杆菌的比例从 80.2%下降到 61.8%（p=0.001）。与 A 组相比，B 组大肠杆菌对氨苄西林、磷霉素和呋喃妥因的耐药率较低（p=0.001、p=0.012 和 p=0.001）。此外，在 7-18 岁的患者中，B 组大肠杆菌的不常见微生物比例较高，对呋喃妥因的耐药率较低（p=0.003 和 p=0.023）。结论：我们的研究表明，持续的 COVID-19 大流行过程导致儿童社区获得性 UTI 发生变化。更卫生的生活方式可能是这种变化的主要因素。
