用于诊断对全身麻醉药过敏反应的点刺试验。

Prick tests in the diagnosis of anaphylaxis to general anaesthetics.

作者信息

Leynadier F, Sansarricq M, Didier J M, Dry J

出版信息

Br J Anaesth. 1987 Jun;59(6):683-9. doi: 10.1093/bja/59.6.683.

DOI:10.1093/bja/59.6.683

Abstract

Pre-charged prick tests and intradermal skin tests (two dilutions) were tested simultaneously in 79 patients using seven drugs (suxamethonium, gallamine, alcuronium, pancuronium, vecuronium, fentanyl and thiopentone) commonly administered during general anaesthesia. Fifty-seven of the patients had suffered anaphylaxis to anaesthetics: 50 had been tested previously (19.5 +/- 13.5 months) by intradermal tests (group 1) and seven were tested for the first time (group 2). Six patients had suffered a side effect during anaesthesia which was unrelated to anaesthetic agents (group 3) and 16 were control subjects (group 4). Prick and intradermal skin tests were simultaneously positive in 98 instances out of 553 (17.7%) and negative in 440 out of 553 (79.6%)--a correlation of 538 out of 553 (97.3%; P less than 0.001). In groups 1, 2 and 3 the correlation was 426 out of 441 (96.6%; P less than 0.001). In group 1, a correlation was observed between the diameters of the weals (r = 0.5; P less than 0.001) obtained by prick and intradermal skin tests, and between the diameters of the flares (r = 0.5; P less than 0.001).

摘要

对79例患者同时进行预充式点刺试验和皮内试验（两种稀释液），使用的是全身麻醉期间常用的7种药物（琥珀胆碱、加拉明、阿库氯铵、泮库溴铵、维库溴铵、芬太尼和硫喷妥钠）。57例患者曾发生过麻醉过敏反应：50例之前已通过皮内试验检测过（19.5±13.5个月）（第1组），7例为首次检测（第2组）。6例患者在麻醉期间出现了与麻醉剂无关的副作用（第3组），16例为对照受试者（第4组）。在553次检测中，点刺试验和皮内试验同时呈阳性的有98例（17.7%），呈阴性的有440例（79.6%）——553例中有538例结果相关（97.3%；P<0.001）。在第1、2和3组中，441例中有426例结果相关（96.6%；P<0.001）。在第1组中，观察到点刺试验和皮内试验产生的风团直径之间存在相关性（r = 0.5；P<0.001），红晕直径之间也存在相关性（r = 0.5；P<0.001）。