Chemistry Centre of Vila Real (CQ-VR), University of Trás-os-Montes and Alto Douro, Vila Real, Quinta de Prados, 5001-801, Portugal.
Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Covilhã, 6201-506, Portugal.
Future Med Chem. 2022 Oct;14(19):1375-1402. doi: 10.4155/fmc-2022-0112. Epub 2022 Sep 7.
Since they were first synthesized in 1965 by Treibs and Jacob, squaraine dyes have revolutionized the polymethine dyes' 'universe' and their potential applications due to their indisputable physical, chemical and biological properties. After 30 years and up to the present, various research teams have dedicated themselves to studying the squaraines' photodynamic therapy application using and models. The various structural modifications made to these compounds, as well as the influence they have shown to have in their phototherapeutic activity, are the main focus of the present review. Finally, the most evident limitations of this class of dyes, as well as future perspectives in the sense of hypothetically successfully overcoming them, are suggested by the authors.
自 1965 年 Treibs 和 Jacob 首次合成以来，由于其无可争议的物理、化学和生物学特性，方酸染料彻底改变了多甲川染料的“世界”及其潜在应用。30 年来，直到现在，各种研究团队一直致力于使用 和 模型研究方酸的光动力疗法应用。对这些化合物进行的各种结构修饰以及它们在光疗活性方面表现出的影响，是本综述的主要重点。最后，作者提出了这类染料最明显的局限性以及未来克服这些局限性的前景。
