de Vries Lisa H, Lodewijk Lutske, de Keizer Bart, Borel Rinkes Inne Hm, Vriens Menno R
Department of Surgery, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Department of Radiology & Nuclear Medicine, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
Future Oncol. 2022 Oct;18(31):3493-3499. doi: 10.2217/fon-2022-0165. Epub 2022 Sep 7.
Sentinel lymph node biopsy (SLNB) is a diagnostic staging procedure. The procedure aims to identify the first draining lymph node(s), which are most likely to contain metastases. SLNB is applied in various cancers, but not currently in thyroid carcinoma. However, treatment strategies are changing, making SLNB clinically relevant. SLNB may lead to more accurate staging, prevent unnecessary treatment and help achieve earlier curation. Ga-tilmanocept PET/computed tomography (CT) can better localize sentinel lymph nodes (SLNs) near the primary tumor than planar scintigraphy and single-photon emission computed tomography (SPECT)/CT. This paper describes the rationale and design of a study investigating SLNB using Ga-tilmanocept PET/CT and indocyanine-green-Tc-nanocolloid in ten differentiated and medullary thyroid carcinoma patients. Localization and number of SLNs, pathology result, optimal scan protocol, surgical time and surgeon's experience are examined. 2021-002470-42 (EudraCT).
前哨淋巴结活检（SLNB）是一种诊断性分期程序。该程序旨在识别最有可能含有转移灶的首个引流淋巴结。SLNB应用于多种癌症，但目前未应用于甲状腺癌。然而，治疗策略正在发生变化，使得SLNB具有临床相关性。SLNB可能会带来更准确的分期，避免不必要的治疗，并有助于实现更早的治愈。与平面闪烁显像和单光子发射计算机断层扫描（SPECT）/CT相比，镓标记替莫西芬正电子发射断层扫描/计算机断层扫描（PET/CT）能更好地定位原发性肿瘤附近的前哨淋巴结（SLN）。本文描述了一项研究的基本原理和设计，该研究使用镓标记替莫西芬PET/CT和吲哚菁绿-锝纳米胶体对10例分化型和髓样甲状腺癌患者进行SLNB研究。研究了SLN的定位和数量、病理结果、最佳扫描方案、手术时间和外科医生的经验。2021-002470-42（欧洲临床试验数据库）
