两种不同的四重α珠蛋白基因排列。
Two different quadruplicated alpha globin gene arrangements.
作者信息
Gu Y C, Landman H, Huisman T H
出版信息
Br J Haematol. 1987 Jun;66(2):245-50. doi: 10.1111/j.1365-2141.1987.tb01306.x.
Abstract
The discovery of two different types of alpha globin gene quadruplication is reported. One with the alpha alpha alpha alpha (anti 3.7)/haplotype was present in four members of a Black family from Georgia, while a second with the alpha alpha alpha alpha (anti 4.2)/haplotype was observed in two members of an Indonesian family. Consistent clinical and haematological manifestations could be observed in these heterozygotes.
摘要
报道了两种不同类型的α珠蛋白基因四重体的发现。一种带有αααα（抗3.7）单倍型，存在于来自佐治亚州的一个黑人家庭的四名成员中，而另一种带有αααα（抗4.2）单倍型，在一个印度尼西亚家庭的两名成员中被观察到。在这些杂合子中可观察到一致的临床和血液学表现。
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