Li Fu-Rong, Liao Jian, Zhu Bin, Li Xia, Cheng Zhiyuan, Jin Cheng, Mo Chunbao, Wu Xianbo, Li Qian, Liang Fengchao
Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China.
School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.
Liver Int. 2023 Feb;43(2):299-307. doi: 10.1111/liv.15416. Epub 2022 Sep 14.
Epidemiological evidence regarding the association of air pollution with the risk of non-alcoholic fatty liver disease (NAFLD) is limited. This study was to examine the associations of long-term exposure to various air pollutants and overall air pollution with risk of incident NAFLD as well as cirrhosis, a major liver-related morbidity for NAFLD.
Included were 456 687 UK residents. Air pollution data included PM , PM , PM , NO and NO . A weighted air pollution score was also generated from PM and NO . Cox proportional hazard models were employed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs).
We identified 4978 cases of NAFLD and 1575 cases of incident cirrhosis, over a median follow-up of 11.9 years. PM , PM , NO and NO exposures contributed to the excess risk of NAFLD associated with air pollution score; and the corresponding adjusted HRs (95% CI) were 1.10 (1.05, 1.14), 1.14 (1.09, 1.20), 1.19 (1.13, 1.24) and 1.11 (1.07, 1.15), respectively, for each interquartile range increase in the above specific air pollutants. Similar patterns were also indicated for cirrhosis risk. Alcohol consumption was an effect modifier for the association between air pollution score and NAFLD risk, whereas body mass index modified the association for cirrhosis risk.
Long-term exposure to air pollution was associated with risks of NAFLD and cirrhosis among the UK population.
空气污染与非酒精性脂肪性肝病（NAFLD）风险之间关联的流行病学证据有限。本研究旨在探讨长期暴露于各种空气污染物和总体空气污染与新发NAFLD风险以及肝硬化（NAFLD的一种主要肝脏相关发病情况）之间的关联。
纳入456687名英国居民。空气污染数据包括细颗粒物（PM）、可吸入颗粒物（PM）、粗颗粒物（PM）、二氧化氮（NO）和一氧化氮（NO）。还根据PM和NO生成了一个加权空气污染评分。采用Cox比例风险模型来估计风险比（HRs）和95%置信区间（CIs）。
在中位随访11.9年期间，我们确定了4978例NAFLD病例和1575例新发肝硬化病例。PM、PM、NO和NO暴露导致了与空气污染评分相关的NAFLD额外风险；上述特定空气污染物每增加一个四分位数间距，相应的调整后HR（95%CI）分别为1.10（1.05，1.14）、1.14（1.09，1.20）、1.19（1.13，1.24）和1.11（1.07，1.15）。肝硬化风险也呈现类似模式。饮酒是空气污染评分与NAFLD风险之间关联的效应修饰因素，而体重指数则修饰了肝硬化风险的关联。
长期暴露于空气污染与英国人群的NAFLD和肝硬化风险相关。
