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被遗忘的幸存者:非霍奇金淋巴瘤生存者的综合综述。

The forgotten survivor: A comprehensive review on Non-Hodgkin lymphoma survivorship.

机构信息

Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

出版信息

Am J Hematol. 2022 Dec;97(12):1627-1637. doi: 10.1002/ajh.26719. Epub 2022 Oct 1.

Abstract

The number of non-Hodgkin lymphoma (NHL) survivors is increasing. With the advancement of NHL therapies, it is crucial to focus on the challenges these survivors may face. Three main categories are to be considered in NHL survivorship, including quality of life and uncertainty about the future, possible physical health complications (including cardiovascular disease, infertility, and subsequent neoplasms), and the impact of novel NHL treatments and their potential complications. The latter includes CAR T-cell therapy, monoclonal antibodies, checkpoint inhibitors, and hematopoietic stem cell transplantation. In this report, we aim to shed the light on these aspects and to discuss survivorship care plan for NHL.

摘要

非霍奇金淋巴瘤(NHL)幸存者的人数正在增加。随着 NHL 治疗方法的进步,关注这些幸存者可能面临的挑战至关重要。NHL 生存者需要考虑三个主要类别,包括生活质量和对未来的不确定性、可能的身体健康并发症(包括心血管疾病、不孕和随后的肿瘤),以及新型 NHL 治疗方法及其潜在并发症的影响。后者包括嵌合抗原受体 T 细胞疗法、单克隆抗体、检查点抑制剂和造血干细胞移植。在本报告中,我们旨在阐明这些方面,并讨论 NHL 的生存者护理计划。

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