围孕期环境因素与巴西中西部地区唇腭裂发生的关系：一项病例对照研究。
Environmental Factors at the Periconceptional Period and the Occurrence of Cleft Lip and Palate in a Midwest Brazil Population: A Case-Control Study.
机构信息
From the University of Cuiabá, Cuiabá, Mato Grosso, Brazil (Ms Silvestre, Dr Silva, Dr R.C.G. da Silva, Dr Bittencourt, Dr Borba, Dr Fernandes, Dr C.A.L. da Silva); General Hospital of Cuiabá, Cuiabá, Mato Grosso, Brazil (Ms Silvestre, Dr R.C.G. da Silva, Dr Borba, Dr Fernandes, Dr C.A.L. da Silva).
出版信息
J Occup Environ Med. 2022 Nov 1;64(11):e751-e756. doi: 10.1097/JOM.0000000000002689. Epub 2022 Sep 2.
OBJECTIVE
To investigate the association between periconceptional environmental exposures and the occurrence of cleft lips and palates.
METHODS
This case-control study analyzed 150 mothers of children with cleft lips and palates living in the same city as 250 mothers whose children did not present with this malformation (controls). Environmental exposure data were gathered through a questionnaire (Latin American Collaborative Study of Congenital Malformations methodology).
RESULTS
Multivariate analysis revealed that monthly income below minimum wage, having another malformed child, other diseases in the first gestational trimester (urinary infection), use of pesticides in home gardens, and pesticide use in farms close to the home were risk factors associated with the malformation, whereas taking vitamins was a protective factor.
CONCLUSION
Maternal and paternal exposure to pesticides is associated with cleft lip and palate in Mato Grosso State, Brazil.
目的
探讨围孕期环境暴露与唇腭裂发生的关系。
方法
本病例对照研究分析了居住在同一城市的 150 名唇腭裂患儿的母亲（病例组）和 250 名无此畸形患儿的母亲（对照组）。通过问卷调查（拉丁美洲先天性畸形合作研究方法）收集环境暴露数据。
结果
多变量分析显示，月收入低于最低工资、有另一个畸形儿、第一个妊娠季度有其他疾病（尿路感染）、在自家花园使用农药以及在靠近家的农场使用农药是与畸形相关的危险因素，而服用维生素则是一种保护因素。
结论
巴西马托格罗索州母亲和父亲接触农药与唇腭裂有关。
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