Department of Pediatrics, Division of Infectious Diseases, CHU Sainte-Justine, Université de Montréal, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada.
Department of Pediatrics, Division of Infectious Diseases, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.
J Pediatric Infect Dis Soc. 2022 Sep 7;11(Supplement_2):S3-S12. doi: 10.1093/jpids/piac052.
Cystic fibrosis (CF) is one of the most common life-shortening genetic diseases in Caucasians. Due to abnormal accumulation of mucus, respiratory failure caused by chronic infections is the leading cause of mortality in this patient population. The microbiology of these respiratory infections includes a distinct set of opportunistic pathogens, including Pseudomonas aeruginosa, Burkholderia spp., Achromobacter spp., Stenotrophomonas maltophilia, anaerobes, nontuberculous mycobacteria, and fungi. In recent years, culture-independent methods have shown the polymicrobial nature of lung infections, and the dynamics of microbial communities. The unique environment of the CF airway predisposes to infections caused by opportunistic pathogens. In this review, we will highlight how the epidemiology and role in disease of these pathogens in CF differ from that in individuals with other medical conditions. Infectious diseases (ID) physicians should be aware of these differences and the specific characteristics of infections associated with CF.
囊性纤维化 (CF) 是白种人中最常见的缩短寿命的遗传疾病之一。由于粘液异常积聚，慢性感染导致的呼吸衰竭是该患者人群死亡的主要原因。这些呼吸道感染的微生物学包括一组独特的机会性病原体，包括铜绿假单胞菌、伯克霍尔德菌属、不动杆菌属、嗜麦芽窄食单胞菌、厌氧菌、非结核分枝杆菌和真菌。近年来，非培养方法显示了肺部感染的多微生物性质和微生物群落的动态变化。CF 气道的独特环境易发生机会性病原体感染。在这篇综述中，我们将重点介绍这些病原体在 CF 中的流行病学和疾病作用如何与其他疾病患者中的情况有所不同。传染病 (ID) 医生应该了解这些差异以及与 CF 相关感染的具体特征。
