Committee on Genetics, Genomics and Systems Biology, The University of Chicago, Chicago, IL 60637, USA; Department of Medicine, Institute of Genomics and Systems Biology, The University of Chicago, Chicago, IL 60637, USA.
Department of Medicine, Institute of Genomics and Systems Biology, The University of Chicago, Chicago, IL 60637, USA.
Cell Rep Med. 2022 Sep 20;3(9):100736. doi: 10.1016/j.xcrm.2022.100736. Epub 2022 Sep 6.
In complex diseases, the phenotypic variability can be explained by genetic variation (G), environmental stimuli (E), and interaction of genetic and environmental factors (G-by-E effects), among which the contribution G-by-E remains largely unknown. In this study, we focus on ten major neuropsychiatric disorders using data for 138,383 United States families with 404,475 unique individuals. We show that, while gene-environment interactions account for only a small portion of the total phenotypic variance for a subset of disorders (depression, adjustment disorder, substance abuse), they explain a rather large portion of the phenotypic variation of the remaining disorders: over 20% for migraine and close to or over 30% for anxiety/phobic disorder, attention-deficit/hyperactivity disorder, recurrent headaches, sleep disorders, and post-traumatic stress disorder. In this study, we have incorporated-in the same analysis-clinical data, family pedigrees, the spatial distribution of individuals, their socioeconomic and demographic confounders, and a collection of environmental measurements.
在复杂疾病中，表型变异性可以通过遗传变异（G）、环境刺激（E）以及遗传和环境因素的相互作用（G-by-E 效应）来解释，其中 G-by-E 的作用在很大程度上仍然未知。在这项研究中，我们使用来自 138383 个美国家庭的 404475 个个体的数据，重点研究了 10 种主要的神经精神疾病。我们表明，尽管基因-环境相互作用仅占某些疾病（抑郁症、适应障碍、物质滥用）总表型方差的一小部分，但它们解释了其余疾病的相当大一部分表型变异：偏头痛超过 20%，焦虑/恐惧障碍、注意缺陷/多动障碍、复发性头痛、睡眠障碍和创伤后应激障碍接近或超过 30%。在这项研究中，我们在同一分析中纳入了临床数据、家族系谱、个体的空间分布、他们的社会经济和人口统计学混杂因素以及一系列环境测量结果。
Zotero 插件
