Hagve T A, Christophersen B O
Biochim Biophys Acta. 1987 Jul 31;920(2):149-54. doi: 10.1016/0005-2760(87)90254-2.
When [14C]linoleic acid (18:2(n-6)) or [14C]dihomogammalinolenic acid (20:3(n-6)) was incubated with isolated liver cells from rats fed an essential fatty acid deficient diet, delta 6- and delta 5-desaturation, chain elongation and synthesis of 14C-labelled C14-C18 fatty acids (from [14C]acetate) were enhanced in female cells compared with male ones. No sex difference in total secretion of very low density lipoproteins (VLDL) was observed. However, VLDL secreted from female cells contained significantly more C16-C18 fatty acids than male cells. It is suggested that the observed sex differences, at least in part, may be related to the different content of fatty acid binding proteins in female cells compared with males.
当用[14C]亚油酸（18:2(n-6)）或[14C]二高-γ-亚麻酸（20:3(n-6)）与喂食必需脂肪酸缺乏饮食的大鼠的分离肝细胞一起孵育时，与雄性细胞相比，雌性细胞中δ6-和δ5-去饱和、链延长以及14C标记的C14-C18脂肪酸（来自[14C]乙酸盐）的合成增强。在极低密度脂蛋白（VLDL）的总分泌方面未观察到性别差异。然而，雌性细胞分泌的VLDL所含的C16-C18脂肪酸明显多于雄性细胞。提示所观察到的性别差异至少部分可能与雌性细胞中脂肪酸结合蛋白的含量与雄性细胞不同有关。
