Li Zelin, Qi Cuijuan, Jia Zhuoya, Zhen Ruoxi, Ren Lin, Jia Yujiao, Chen Shuchun
Graduate School of Hebei Medical University, People's Republic of China.
Department of Endocrinology, Hebei General Hospital, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 Aug 31;15:2643-2652. doi: 10.2147/DMSO.S371457. eCollection 2022.
To study the correlation between estimated glucose disposition rate (eGDR) and coagulation parameters in type 2 diabetes patients (T2DM).
A total of 948 patients suffering from T2DM were enrolled for this research. Various blood coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen (FIB) were assessed. Body mass index (BMI), hypertension, and the levels of glycated hemoglobin (HbA1c) were used to calculate the patients' eGDRs. All patients were sorted into two groups: those with high eGDRs (eGDR≥7.5) and those with low eGDRs (eGDR<7.5). The patients were then separated into groups of men and women. The connection between eGDR and coagulation indexes was examined using Spearman correlation, Pearson correlation, and multiple linear regression analysis.
In comparison to the high-eGDR group, reduced PT and APTT levels with increased FIB levels were observed in the low-eGDR group ( =0.006, <0.001, and = 0.035, respectively). The eGDR showed a positive relation with APTT (r = 0.142, < 0.001), a negative relation with FIB (r = -0.082, = 0.012), and no correlation with PT (r =0.064, =0.050) in the all patients. As well as, the eGDR demonstrated a positive relation with APTT (r = 0.173, < 0.001), a negative relation with FIB (r = -0.093, = 0.03), and no relation with PT (r = 0.045, = 0.300) in the male subgroups. Additionally, this correlation persisted following the adjustment of other factors in multilinear regression analysis. However, the female subgroup demonstrated no correlation among eGDR and PT, APTT or FIB (r = 0.086, = 0.083, r = 0.097, = 0.05;r = -0.058, = 0.240, respectively).
Our study is the first to prove that eGDR demonstrates a correlation with coagulation indexes in T2DM patients. And, this correlation is gender-specific.
研究2型糖尿病患者（T2DM）的估计葡萄糖处置率（eGDR）与凝血参数之间的相关性。
本研究共纳入948例T2DM患者。评估了包括凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和纤维蛋白原（FIB）在内的各种凝血参数。使用体重指数（BMI）、高血压和糖化血红蛋白（HbA1c）水平来计算患者的eGDR。所有患者分为两组：高eGDR组（eGDR≥7.5）和低eGDR组（eGDR<7.5）。然后将患者按男女分组。使用Spearman相关性、Pearson相关性和多元线性回归分析来检查eGDR与凝血指标之间的联系。
与高eGDR组相比，低eGDR组观察到PT和APTT水平降低，FIB水平升高（分别为P = 0.006、P<0.001和P = 0.035）。在所有患者中，eGDR与APTT呈正相关（r = 0.142，P<0.001），与FIB呈负相关（r = -0.082，P = 0.012），与PT无相关性（r = 0.064，P = 0.050）。此外，在男性亚组中，eGDR与APTT呈正相关（r = 0.173，P<0.001），与FIB呈负相关（r = -0.093，P = 0.03），与PT无相关性（r = 0.045，P = 0.300）。此外，在多线性回归分析中调整其他因素后，这种相关性仍然存在。然而，女性亚组中eGDR与PT、APTT或FIB之间无相关性（分别为r = 0.086，P = 0.083；r = 0.097，P = 0.05；r = -0.058，P = 0.240）。
我们的研究首次证明eGDR与T2DM患者的凝血指标相关。而且，这种相关性具有性别特异性。
