尼日利亚一家教学医院的抗生素使用情况研究。
Antibiotic utilization study in a teaching hospital in Nigeria.
作者信息
Sekoni Kehinde F, Oreagba Ibrahim A, Oladoja Farouk A
机构信息
Department of Pharmacology, Therapeutics and Toxicology Faculty of Basic Medical Science, University of Lagos, Akoka, Lagos-State, Nigeria.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Olabisi Onabanjo University, Ago-Iwoye, Ogun-State, Nigeria.
出版信息
JAC Antimicrob Resist. 2022 Sep 5;4(5):dlac093. doi: 10.1093/jacamr/dlac093. eCollection 2022 Oct.
BACKGROUND
Antibiotics have been the bedrock of modern medical care, particularly bacterial infections. However, globally, antimicrobial resistance has become a well-recognized public health threat in recent years, and interventions to reduce its burden have been launched worldwide.
OBJECTIVES
The present study evaluated antibiotic utilization in both hospitalized patients and outpatients in a University Hospital in Nigeria.
METHODS
In a 3 year retrospective study between January 2017 and December 2019, 246 case files of patients were selected for the study based on inclusion and exclusion criteria. In addition, the antibiotic consumption rate for hospitalized and outpatients was determined.
RESULTS
The total antibiotic consumption for hospitalized patients in this study was 260.9 DDD/100 bed-days, while the outpatient department's patients were 72.3 DDD/1000 inhabitants per day. Peptic ulcer disease was the most frequent indication for antibiotic use for outpatients, with the fluoroquinolones and macrolides being the most prescribed antibiotic class and antibiotic class with the highest DDD, respectively. The most frequent indication for antibiotic use for hospitalized patients was chronic kidney diseases, with the fluoroquinolones and second-generation cephalosporins being the most prescribed antibiotic class and antibiotic class with the highest DDD, respectively. DDD per 100 bed-days and DDD per 1000 patient-days were highest in 2018. The values for the years were 0.019, 0.195 and 0.001 for 2017, 2018 and 2019, respectively.
CONCLUSIONS
Our findings revealed irrationality in antibiotic use. Therefore, antimicrobial stewardship programmes should be implemented.
背景
抗生素一直是现代医疗护理的基石，尤其是在治疗细菌感染方面。然而，近年来，全球范围内抗菌药物耐药性已成为公认的公共卫生威胁，世界各地已开展了减轻其负担的干预措施。
目的
本研究评估了尼日利亚一家大学医院住院患者和门诊患者的抗生素使用情况。
方法
在一项2017年1月至2019年12月的3年回顾性研究中，根据纳入和排除标准选择了246例患者的病例档案进行研究。此外，还确定了住院患者和门诊患者的抗生素消耗率。
结果
本研究中住院患者的抗生素总消耗量为260.9限定日剂量/100床日，而门诊部患者为72.3限定日剂量/1000居民/天。消化性溃疡病是门诊患者使用抗生素最常见的指征，氟喹诺酮类和大环内酯类分别是处方量最大的抗生素类别和限定日剂量最高的抗生素类别。住院患者使用抗生素最常见的指征是慢性肾脏病，氟喹诺酮类和第二代头孢菌素分别是处方量最大的抗生素类别和限定日剂量最高的抗生素类别。每100床日的限定日剂量和每1000患者日的限定日剂量在2018年最高。2017年、2018年和2019年的数值分别为0.019、0.195和0.001。
结论
我们的研究结果显示抗生素使用存在不合理性。因此，应实施抗菌药物管理计划。
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