Ren Weifu, Bian Qi, Cai Yan
Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Nephrology, Changhai Hospital, Naval Medical University, Shanghai, China.
Front Mol Biosci. 2022 Aug 17;9:976298. doi: 10.3389/fmolb.2022.976298. eCollection 2022.
Kidney disease is a global health concern with an enormous expense. It is estimated that more than 10% of the population worldwide is affected by kidney disease and millions of patients would progress to death prematurely and unnecessarily. Although creatinine detection and renal biopsy are well-established tools for kidney disease diagnosis, they are limited by several inevitable defects. Therefore, diagnostic tools need to be upgraded, especially for the early stage of the disease and possible progression. As one of the most common post-translational modifications of proteins, N-glycosylation plays a vital role in renal structure and function. Deepening research on N-glycosylation in kidney disease provides new insights into the pathophysiology and paves the way for clinical application. In this study, we reviewed recent N-glycosylation studies on several kidney diseases. We also summarized the development of mass spectrometric methods in the field of N-glycoproteomics and N-glycomics.
肾脏疾病是一个全球性的健康问题，费用高昂。据估计，全球超过10%的人口受到肾脏疾病的影响，数百万患者会过早且不必要地走向死亡。尽管肌酐检测和肾活检是肾脏疾病诊断的成熟工具，但它们存在一些不可避免的缺陷。因此，诊断工具需要升级，特别是针对疾病的早期阶段和可能的进展情况。作为蛋白质最常见的翻译后修饰之一，N-糖基化在肾脏结构和功能中起着至关重要的作用。对肾脏疾病中N-糖基化的深入研究为病理生理学提供了新的见解，并为临床应用铺平了道路。在本研究中，我们回顾了最近关于几种肾脏疾病的N-糖基化研究。我们还总结了N-糖蛋白质组学和N-糖组学领域质谱方法的发展。
