Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, China.
Jinan City People's Hospital, Jinan, China.
Contrast Media Mol Imaging. 2022 Aug 16;2022:9833941. doi: 10.1155/2022/9833941. eCollection 2022.
The purpose of this study was to investigate the absolute value of peripheral blood lymphocytes in patients with primary immune thrombocytopenia and the diagnostic effect on patients with primary immune thrombocytopenia. From January 2020 to June 2021, 76 patients with primary immune thrombocytopenia and 80 healthy check-ups admitted to our hospital were selected as study subjects and divided into a control group (80 patients, healthy check-ups) and an observation group (76 patients, primary immune thrombocytopenia), according to the health status of the organism. Early morning fasting venous blood was collected from both groups, and the absolute value of peripheral blood lymphocytes was measured and compared using a fully automated hematology analyzer to investigate the diagnostic value of absolute peripheral blood lymphocytes in primary immune thrombocytopenia. The CD3+, CD3+CD4+, CD4+/CD8+, and CD16+CD56+ assay values in the observation group were lower than those in the control group, and the CD3+CD8+, CD19+, and ALC assay values were higher than those in the control group ( < 0.05). The CD3+CD8+ detection values of newly diagnosed patients were similar to those of relapsed refractory patients ( > 0.05); CD3+, CD3+CD4+, CD4+/CD8+, and CD16+CD56+ detection values of newly diagnosed patients were lower than those of relapsed refractory patients, and CD19+ and ALC detection values were higher than those of relapsed refractory patients; CD3+, CD3+CD4+, CD4+, CD4+/CD8+, and CD16+CD56+ detection values of mild patients were lower than those of relapsed refractory patients; CD3+, CD3+CD4+, CD4+/CD8+, and CD16+CD56+ detection values were higher in mild patients than in severe patients, and CD3+CD8+, CD19+, and ALC detection values were lower than in severe patients ( < 0.05). The absolute lymphocyte values were of high diagnostic value in primary immune thrombocytopenia, with a sensitivity and specificity of 93.42% and 90.00%. The application of absolute peripheral blood lymphocyte value in the clinical diagnosis of primary immune thrombocytopenia can achieve a better detection and diagnosis effect, which has a positive impact on the early diagnosis rate and can help patients to obtain more timely, effective and targeted treatment, and is worthy of promotion.
本研究旨在探讨原发性免疫性血小板减少症患者外周血淋巴细胞绝对值及其对原发性免疫性血小板减少症的诊断效果。选取 2020 年 1 月至 2021 年 6 月我院收治的 76 例原发性免疫性血小板减少症患者和 80 例健康体检者作为研究对象，根据机体健康状况分为对照组（80 例，健康体检者）和观察组（76 例，原发性免疫性血小板减少症）。两组均于清晨空腹采集静脉血，采用全自动血液分析仪检测外周血淋巴细胞绝对值，并比较两组患者的检测结果，以探讨外周血淋巴细胞绝对值对原发性免疫性血小板减少症的诊断价值。观察组 CD3+、CD3+CD4+、CD4+/CD8+、CD16+CD56+检测值均低于对照组，CD3+CD8+、CD19+、ALC 检测值均高于对照组（<0.05）。初诊患者 CD3+CD8+检测值与复发难治患者比较，差异无统计学意义（>0.05）；初诊患者 CD3+、CD3+CD4+、CD4+/CD8+、CD16+CD56+检测值均低于复发难治患者，CD19+、ALC 检测值均高于复发难治患者；轻度患者 CD3+、CD3+CD4+、CD4+、CD4+/CD8+、CD16+CD56+检测值均低于复发难治患者；轻度患者 CD3+、CD3+CD4+、CD4+/CD8+、CD16+CD56+检测值均高于重度患者，CD3+CD8+、CD19+、ALC 检测值均低于重度患者（<0.05）。外周血淋巴细胞绝对值对原发性免疫性血小板减少症具有较高的诊断价值，其灵敏度和特异度分别为 93.42%、90.00%。外周血淋巴细胞绝对值在原发性免疫性血小板减少症的临床诊断中应用，能达到较好的检测和诊断效果，对提高早期诊断率有积极影响，能帮助患者获得更及时、有效、有针对性的治疗，值得推广。
