Nuti R, Turchetti V, Martini G, Righi G, Galli M, Loré F
Biomed Pharmacother. 1987;41(2):96-100.
In order to clarify the pathophysiological mechanisms of spasmophilia, 34 subjects (31 females and 3 males) with spasmophilia were studied. The diagnosis of spasmophilia was based on a specific clinical protocol and electromyographic criteria. In the study, markedly reduced plasma ionized calcium and serum magnesium concentrations were observed together with slightly and non-significantly reduced plasma calcium and phosphate levels. An impairment of intestinal radiocalcium absorption was also noticed. Parathyroid secretion did not show any significant disturbance, but circulating calcitonin levels were found to be significantly lower than in normal subjects. The mean value of serum 25OHD was within the normal range, while a slight reduction in bone Gla protein, an index of osteoblastic activity, was detected. No difference between patients with spasmophilia and normal subjects was observed concerning 47Ca kinetics in red blood cells. The studies indicated that an impaired intestinal calcium transport together with low levels of circulating calcitonin represent the most important pathophysiological determinants of spasmophilia.
为了阐明易痉挛症的病理生理机制，对34名易痉挛症患者（31名女性和3名男性）进行了研究。易痉挛症的诊断基于特定的临床方案和肌电图标准。在该研究中，观察到血浆离子钙和血清镁浓度显著降低，同时血浆钙和磷酸盐水平略有降低但无显著差异。还注意到肠道放射性钙吸收受损。甲状旁腺分泌未显示任何明显紊乱，但发现循环降钙素水平明显低于正常受试者。血清25OHD的平均值在正常范围内，而骨钙素（成骨细胞活性指标）略有降低。在红细胞47Ca动力学方面，易痉挛症患者与正常受试者之间未观察到差异。研究表明，肠道钙转运受损以及循环降钙素水平低是易痉挛症最重要的病理生理决定因素。
