Butturini L, Pelà G, Pedrazzoni M, Saginario M
Biomed Pharmacother. 1987;41(3):148-51.
Calcitonin (CT) secretion following stimulation was studied in 9 young women suffering from spasmophilia, this having been diagnosed by clinical and electromyographic criteria. The controls were 9 women, matched by age, who responded negatively to the diagnostic tests. After rapid intravenous infusion (60 sec) of 4 mg/kg/lean body mass of calcium (as gluconate), CT concentration increased measurably (p less than 0.0001) in the controls, while remaining unchanged in the spasmophilic. The average increase per cent vs. the baseline values was 225% in the controls and 34% in those with spasmophilia (p less than 0.005). 5 out of 9 of the patients showed a completely flat curve. This finding, due to a diminished CT reserve in spasmophilia, may be considered a possible diagnostic feature as well as a fundamental pathological element in the reduction of the intracellular calcium pool responsible for the neuromuscular hyperexcitability. Moreover, the therapeutic use of the hormone in this condition is to be encouraged.
对9名患有痉挛素质的年轻女性进行了刺激后降钙素（CT）分泌的研究，痉挛素质已通过临床和肌电图标准进行诊断。对照组为9名年龄匹配的女性，她们对诊断测试反应为阴性。在以4mg/kg/去脂体重快速静脉输注（60秒）钙（葡萄糖酸钙）后，对照组的CT浓度显著增加（p<0.0001），而痉挛素质患者的CT浓度保持不变。与基线值相比，对照组平均增加百分比为225%，痉挛素质患者为34%（p<0.005）。9名患者中有5名显示曲线完全平坦。由于痉挛素质患者CT储备减少，这一发现可被视为一种可能的诊断特征，也是导致神经肌肉兴奋性增高的细胞内钙池减少的一个基本病理因素。此外，鼓励在这种情况下使用该激素进行治疗。
