Qiu Shangkun, Liu Qicong, Yuan Ya, Zhou Hong, Zeng Bin
College of Pharmacy, Shenzhen Technology University, Shenzhen, China.
Jiangxi Province Center for Disease Control and Prevention, Nanchang, China.
Front Genet. 2022 Aug 22;13:984343. doi: 10.3389/fgene.2022.984343. eCollection 2022.
It is well-known that excessive cholesterol leads to hypercholesterolemia, arteriosclerosis, coronary heart disease, stroke, and other diseases, which seriously threatens human health. , a prokaryote, is reported to utilize cholesterol in the environment. However, little research focuses on the cholesterol utilization by eukaryote. Hence, the objectives of the present study were to investigate the mechanism of cholesterol utilization by the eukaryote and determine the role of oxysterol binding protein in this process. Our results showed for the first time that , a food-safe filamentous fungus, can utilize cholesterol efficiently. Our results also demonstrated that cholesterol utilization by might promote the conversion of ergosterol to ergosterol peroxide. Osh3, an oxysterol binding protein, can bind sterols (e.g., cholesterol, ergosterol, and ergosterol peroxide) and plays an important role in sterols transportation. This research is of considerable significance for developing low-fat food and cholesterol-lowering probiotics.
众所周知，过量的胆固醇会导致高胆固醇血症、动脉硬化、冠心病、中风和其他疾病，严重威胁人类健康。据报道，一种原核生物能利用环境中的胆固醇。然而，很少有研究关注真核生物对胆固醇的利用。因此，本研究的目的是探究真核生物利用胆固醇的机制，并确定氧甾醇结合蛋白在此过程中的作用。我们的结果首次表明，一种食品安全性丝状真菌能高效利用胆固醇。我们的结果还证明，该真菌对胆固醇的利用可能会促进麦角固醇向麦角固醇过氧化物的转化。氧甾醇结合蛋白Osh3能结合甾醇（如胆固醇、麦角固醇和麦角固醇过氧化物），并在甾醇运输中起重要作用。本研究对于开发低脂食品和降胆固醇益生菌具有重要意义。
