Bourry J, Gioanni J, Ettore F, Giacomini M A, Simon J M, Courdi A
Biomed Pharmacother. 1987;41(3):151-5.
The labeling index (LI), representing the percentage of S-phase cells, was measured in the healthy colorectal mucosa of subjects without a personal or familial history of neoplasm as well as in persons with a positive history, and was compared to the LI in benign or malignant lesions in a total of 128 subjects. In the healthy mucosa, LI was lowest in control subjects; it rose progressively in patients with a personal history of adenoma, patients with non colorectal cancer, and colorectal cancer patients respectively. There was a significant increase in LI from healthy mucosa to adenoma to carcinoma. The pattern of labeling in the crypts was studied in 56 subjects with different familial and personal histories. Limitation of labeling to the deepest part of the crypts was observed in control subjects and to a lesser extent in the healthy mucosa of patients with adenoma. An upward shift of the proliferative zone was observed in patients with a personal or familial history of cancer; adenomatous lesions had an inverse labeling distribution: labeling decreased from the luminal aspect towards the deep segments. High LI values and a shift of the proliferative zone towards the surface of the crypt may identify individuals at high risk for cancer of the colon and rectum.
标记指数（LI）代表S期细胞的百分比，在无个人或家族肿瘤病史的受试者的健康结直肠黏膜以及有阳性病史的人群中进行测量，并与总共128名受试者的良性或恶性病变中的LI进行比较。在健康黏膜中，LI在对照受试者中最低；在有腺瘤个人病史的患者、非结直肠癌患者和结直肠癌患者中分别逐渐升高。从健康黏膜到腺瘤再到癌，LI有显著增加。对56名有不同家族和个人病史的受试者的隐窝标记模式进行了研究。在对照受试者中观察到标记局限于隐窝的最深部分，在有腺瘤患者的健康黏膜中程度较轻。在有个人或家族癌症病史的患者中观察到增殖区向上移位；腺瘤性病变具有相反的标记分布：标记从腔面朝向深部节段减少。高LI值和增殖区向隐窝表面的移位可能识别出患结直肠癌风险高的个体。
