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金水宝胶囊治疗糖尿病肾病有效性和安全性的系统评价和 Meta 分析: 随机对照试验研究。

Efficacy and Safety of Jinshuibao Capsule in Diabetic Nephropathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

机构信息

Center for Treatment of Diseases, Nanchang Hongdu Hospital of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.

Academician Workstation, Jiangxi University of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.

出版信息

Comput Math Methods Med. 2022 Aug 28;2022:9671768. doi: 10.1155/2022/9671768. eCollection 2022.

DOI:10.1155/2022/9671768
PMID:36072775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9441367/
Abstract

OBJECTIVE

This systematic review was able to evaluate the clinical evidence of JSBC in the randomized controlled trial (RCT) of diabetic nephropathy.

METHODS

The Chinese and English literatures published in PubMed, Cochrane Library, VIP, Wanfang Data, CNKI, and CBM before July 30, 2019, were retrieved. This study includes only randomized controlled trials of treatments related to diabetic nephropathy. We assessed the methodological quality of the subjects involved according to the assessment criteria in 5.3.3 of the Cochrane Assessment Manual. RevMan 3.5.5 software was used to analyze the relevant data, meta-analysis, and inverted funnel analysis chart.

RESULTS

This study included 26 RCTs, including 4676 patients in total (2342 cases in the experimental group and 2334 cases in the control group). The results of 8 randomized controlled trials showed that urinary microprotein excretion rate (UAER) significantly decreased ( < 0.0001) before and after treatment of diabetic nephropathy.

CONCLUSION

The available clinical evidence has suggested that JSBC combined with western drugs is differentially effective in the treatment of diabetic nephropathy. The combination of JSBC with western medicine is more effective. However, due to the small amount and low quality of the included literatures, the current evidence is not certain to be fully clinically applicable.

摘要

目的

本系统评价能够评估 JSBC 在糖尿病肾病随机对照试验（RCT）中的临床证据。

方法

检索 2019 年 7 月 30 日前 Pubmed、Cochrane Library、VIP、万方数据、CNKI、CBM 发表的中英文文献，本研究仅纳入与糖尿病肾病治疗相关的随机对照试验。根据 Cochrane 评估手册 5.3.3 的评估标准，我们评估了受试者的方法学质量。使用 RevMan 3.5.5 软件分析相关数据，进行荟萃分析和倒漏斗图分析。

结果

本研究共纳入 26 项 RCT，共 4676 例患者（实验组 2342 例，对照组 2334 例）。8 项随机对照试验的结果表明，糖尿病肾病治疗前后尿微量蛋白排泄率（UAER）明显降低（<0.0001）。

结论

现有临床证据表明，JSBC 联合西药治疗糖尿病肾病有一定疗效。JSBC 联合西药治疗效果更佳。但是，由于纳入文献数量少，质量低，目前的证据尚不能完全适用于临床。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/e2dbf1f3216b/CMMM2022-9671768.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/afbc439d16b4/CMMM2022-9671768.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/a2530a037022/CMMM2022-9671768.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/3c508096d2f4/CMMM2022-9671768.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/45f0bb1876d2/CMMM2022-9671768.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/f76455f1086d/CMMM2022-9671768.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/4ffa45883c52/CMMM2022-9671768.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/3f4e5144e910/CMMM2022-9671768.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/e2dbf1f3216b/CMMM2022-9671768.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/afbc439d16b4/CMMM2022-9671768.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/a2530a037022/CMMM2022-9671768.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/3c508096d2f4/CMMM2022-9671768.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/45f0bb1876d2/CMMM2022-9671768.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/f76455f1086d/CMMM2022-9671768.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/4ffa45883c52/CMMM2022-9671768.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/3f4e5144e910/CMMM2022-9671768.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/993e/9441367/e2dbf1f3216b/CMMM2022-9671768.008.jpg

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